MCQs on Pathology of Cell Proliferation and Neoplasia - General Pathology MCQs

# The reversible change including the replacement of one type of adult cells with the other type is called:
A. Hyperplasia
B. Metaplasia
C. Dysplasia
D. Neoplasia

# The disordered reversible cellular changes such as pleomorphism, nuclear hyperchromatin are seen in:
A. Hyperplasia
B. Metaplasia
C. Dysplasia
D. Neoplasia



# When the cells in malignancy resemble their undifferentiated primitive cells, they are said to be:
A. Anaplastic
B. Dysplastic
C. Hyperplastic
D. Metaplasia

# Which of the following is not a feature of neoplasia?
A. Aplasia
B. Anaplasia
C. Abnormal mitosis
D. Pleomorphism

# Lack of differentiation of cells is known as:
A. Anaplasia
B. Metaplasia
C. Dysplasia
D. Hypertrohpy

# The most common type of epithelial metaplastic changes seen in bronchial mucosa of cigarette smokers is:
A. Cuboidal cells to columnar cells
B. Squamous cells to cuboid cells
C. Cuboidal to stratified squamous cells
D. Columnar to cuboidal cells

# There is increase in the size of heart following myocardial infarction or long standing hypertension. This is an example of:
A. Hyperplasia
B. Hypertrophy
C. Metaplasia
D. Hyperplastic

# The increase in the size of uterus during pregnancy is an example of:
A. Hyperplasia
B. Hypertrophy
C. Both of the above
D. None of the above

# Which of the following are correctly matched?
A. Increase in size of breast during puberty - Physiological hyperplasia
B. Increase in size of cardiac muscle and skeletal muscle - Hypertrophy
C. Increase in the size of left kidney following removal of right kidney - Compensatory hyperplasia
D. All of the above

# Which of the following constituents of tobacco are carcinogens?
A. Nitrosamine, N-nitrosonornicotine (NNN), nicotine
B. Polycyclic aromatic hydrocarbons, benzopyrene, phenol
C. Benzopyrene, Carbon mono oxide, formaldehyde
D. Nicotine, benzopyrene, phenol

# A simple bacterial test for mutagenic carcinogens is:
A. Ames test
B. Redox test
C. Bacteriophage
D. Gene splicing

# All the following methods are used to detect mutations EXCEPT:
A. Single stranded conformational polymorphism
B. Denaturating gradient gel electrophoresis
C. Gel electrophoresis
D. Northern blot analysis

# All of the following are oncogenes EXCEPT:
A. ABL
B. BCR
C. AML
D. PTC

# Presence of dermoid cyst in ovary is and example of:
A. Choristoma
B. Hamartoma
C. Neoplasia
D. Teratoma

# A benign tumor of smooth muscle such as myometrium of uterus is called:
A. Leiomyoma
B. Rhabdomyoma
C. Leiomyosarcoma
D. Rhabdomyosarcoma

# Neoplasia of blood vessel is called:
A. Angioma
B. Haematoma
C. Lymphosarcoma
D. Papilloma

# Which of the following is not a precancerous condition?
A. Senile keratosis
B. Seborrhic keratosis
C. Erythroplakia
D. Leukoplakia

# Compared to normal cellular growth, cell growth in neoplasm is:
A. 10 times greater than normal cell growth
B. Never exceeds normal cell growth
C. Very rapid
D. Is very less than normal cell growth

# Which of the following is not a feature of malignant neoplasm?
A. Invasion
B. Encapsulation
C. Metastasis
D. Anaplasia

# The most definite feature of a malignant tumor is:
A. Hemorrhage
B. Increased mitoses
C. Metastasis
D. Necrosis

# The most characteristic feature of a neoplasm as opposed to inflammatory overgrowth is:
A. Abnormal mitosis
B. Size of the lesion
C. Progressive growth after removal of causative stimuli
D. Tendency to grow rapidly

# The tumor that is highly radiosensitive but not radiocurable is:
A. Squamous cell carcinoma
B. Malignant lymphoma
C. Ewing's sarcoma
D. Osteoblastoma

# Which of the following is most radiosensitive neoplasm of oral cavity?
A. Squamous cell carcinoma
B. Basal cell carcinoma
C. Fibroma
D. Osteogenic sarcoma

# From which of the following surfaces a basal cell carcinoma can develop?
A. Cutaneous side of lip
B. Mucosal side of lip
C. Lining mucosa of cheek
D. Palate

# Which of the following is true of basal cell carcinoma?
A. It is also called rodent ulcer and is a well differentiated tumor arising from adnexa of skin
B. It is common in middle third of face below canthal line and above ala tragus line
C. It hardly shows metastasis and is fixed to underlying skin
D. All of the above

# Tumor which shows poor differentiation with immature anaplastic cells and increased mitosis are generally:
A. Radioresistant
B. Radiosensitive
C. Radiostable
D. Radiorefractive

# Squamous cell carcinoma of oraal cavity closely resembles:
A. Cancer of cervix
B. Cancer of breast
C. Carcinoma of lung
D. Malignant lymphoma

# The most common malignancies found in males are:
A. Lung and oral cavity
B. Brain and parotid
C. Prostate and parotid
D. Brain and prostate

# In which of the following conditions serum acid phosphatase levels are increased?
A. Prostate gland carcinoma
B. Oat cell carcinoma
C. Squamous cell carcinoma of oral cavity
D. All of the above

# A benign tumor developing from glands is called:
A. Adenoma
B. Fibroma
C. Lipoma
D. Nevus

# A patient with a history of cigarette smoking develops weight loss, difficulty in swallowing, and sudden change in voice. The most likely diagnosis:
A. Carcinoma of larynx
B. Carcinoma of oropharynx
C. Laryngitis
D. Pharyngitis

# Which of the following has best prognosis?
A. Malignant melanoma
B. Squamous cell carcinoma
C. Basal cell carcinoma
D. Osteosarcoma

# Which of the following tumor shows formation of epithelial pearls and intercellular bridges?
A. Well differentiated squamous cell carcinoma
B. Osteosarcoma
C. Malignant melanoma
D. All of the above

# Which of the following is true of Hodgkin's lymphoma?
A. Malignant neoplasm commonly seen in young adults
B. Mirror imaged Reed-Sternberg cell is the diagnostic characteristic of the lymph node
C. Ingestion of alcohol elicits pain in involved lymphnode
D. All of the above

# Burkitt's lymphoma is associated with the proliferation of:
A. T cells
B. B cells
C. Lymph vessels
D. Lymph nodes

# A tumor characterized by rapid rate of growth which almost doubles its size by next day is:
A. Hodgkin's lymphoma
B. Malignant melanoma
C. African Burkitt's jaw lymphoma
D. Squamous cell carcinoma

# It is a bone tumor containing plasma cells showing hyperimmunoglobulinaemia, light chain dimers (Bence-Jones proteins) in urine. The tumor we are talking about is:
A. Hodgkin's tumor
B. Leukemia
C. Multiple myeloma
D. Osteosarcoma

# Which of the following is least related to prognosis of a malignant melanoma?
A. Degree of pigmentation
B. Depth of Invasion
C. Lymphadenopathy
D. Pallor

# The wasting syndrome associated in cancer is called:
A. Achalasia
B. Cachexia
C. Atelexis
D. Cacogeusia

# Immune response to tumor is mediated by:
A. Cytotoxic T lymphocytes
B. Natural killer cells
C. Humoral mechanism
D. All of the above

# Most potent stimulators of naive T cells are:
A. Follicular dendritic cells
B. Mature dendritic cells
C. Mast cells
D. B lymphocytes

# Immunohistochemistry is mainly employed for which of the following processes?
A. To localize the cell of origin of tumor
B. To distinguish benign and malignant lesions
C. To distinguish neoplastic from non neoplastic proliferations
D. To detect autoantibodies in the serum

# PAP smear is used to detect dysplasia, carcinoma in situ and invasive carcinoma of uterine cervix. This is based on the principle of:
A. Neoplastic cells are cohesive
B. Neoplastic cells are non cohesive
C. Hyperchromatic and pleomorphism of tumor cells
D. All of the above

# Exfoliative cytology is indicated in:
A. Heavily keratinized lesions of oral cavity
B. Pre cancerous lesions of oral cavity
C. Cigarette smokers
D. Mass screening of cervical cancer

# A 43 year old man comes to the physician because of a black growth on his right hand. He first noticed this 'growth' about 6 months ago, and it has been getting progressively darker and larger. A biopsy is taken from the center of the lesion and is sent to pathology for microscopic examination. Which of the following markers will be the most helpful in establishing the diagnosis?
A. CD markers
B. CA 19-9
C. CA-125
D. S 100

# Prostate specific antigen is used as:
A. Tumor marker
B. Proto-oncogene
C. Oncogene
D. Bacterial antigen

# Onion skin appearance is seen in:
A. Ewing's sarcoma
B. Osteosarcoma
C. Osteoma
D. Fibrosarcoma

# Round cell tumor of bone is:
A. African jaw lymphoma
B. Multiple myeloma
C. Ewing's sarcoma
D. Osteogenic Sarcoma

# Sunburst appearance and Codman's triangle are seen in:
A. Osteosarcoma
B. Fibrosarcoma
C. Chondrosarcoma
D. None of the above

# The most common malignant lesion of bone is:
A. Osteosarcoma
B. Osteochondroma
C. Ewing's sarcoma
D. Metastatic carcinoma

# Usually metastatic lesions are osteolytic, but osteoblastic secondaries occur in cancer of:
A. Thyroid
B. Prostate
C. Kidney
D. Uterus

# The lesion of bone which is expansile and eccentrically ballooned out is:
A. Ossifying fibroma
B. Aneurysmal bone cyst
C. Fibrous dysplasia
D. None of the above

# Old male demonstrates urinary retention and difficulty in voiding his bladder. He may be suffering most likely from:
A. Prostate malignant neoplasm
B. Benign nodular prostatic hyperplasia
C. Malignant neoplasm of bladder
D. Neoplasm of testicles

# The basic effect of radiation on living tissue is:
A. Denaturation
B. Precipitation
C. Ionisation
D. All of the above

# Least sensitive phase of a cell cycle to radiation is:
A. S phase
B. G1 phase
C. G2 phase
D. M phase

# Which of the following is most radiosensitive?
A. Spermatogonium
B. Endothelium
C. Smooth muscle
D. Alimentary canal lining

# The least radiosensitive cell is:
A. Endothelium
B. Alimentary canal mucosal cells
C. Lining smooth muscle cells
D. Osteocyte

# Most radiosensitive among the following is:
A. Lymphocytes
B. Endothelial cells
C. Nerve cells
D. Muscle cell

# The radiosensitivity of a tissue is dependent on:
A. Type of cells and their mitotic rate
B. Size of cells and their cytoplasmic content
C. Amount of RNA in the cytoplasm
D. All of the above

# Which of the following adult cells have no ability to proliferate?
A. Neurons of CNS, skeletal and cardiac muscle cells
B. Smooth muscle cells, fibroblasts, vascular endothelium and bone and cartilage cells
C. Haematopoietic cells of bone marrow and cells of lymph nodes and spleen
D. Surface epithelial cells, lining mucosa of alimentary, respiratory and urinary tracts

# Which of the following cells have no capacity for regeneration ?
A. Neurons
B. Smooth muscle cells
C. Haemopoietic cells of bone marrow
D. Parenchyma of liver