Palmar and plantar hyperkeratosis is a feature of:

 # Palmar and plantar hyperkeratosis is a feature of:

 A. Down syndrome

B. Papillon Lefevre Syndrome

C. Chediak-Higashi Syndrome

D. Klinefelter syndrome

The correct answer is B. Papillon Lefevre Syndrome.

Papillon-Lefevre Syndrome 

1. This is characterized by hyperkeratotic skin lesions and severe destruction of the periodontium. 

2. These changes may appear before the age of 4 years. 

3. Skin lesions are—hyperkeratosis of localized areas on palms, soles, knees, and elbows. 

4. Periodontal involvement is early inflammatory changes that lead to bone loss and exfoliation of teeth. Primary teeth are lost by 5 or 6 years of age. The permanent dentition erupts normally but the permanent teeth are lost within a few years.