Major and frequent influence for arterial thrombus formation is:

 # Major and frequent influence for arterial thrombus formation is:

a) Alteration in blood flow

b) Hypercoagulability

c) Endothelial damage

d) Fatty streak

The correct answer is C. Endothelial damage.

For a single-choice question on thrombus formation, the answer depends on the clinical context:

1. Arterial Thrombosis (e.g., Myocardial Infarction)

Correct Answer: [c) Endothelial Damage]

Rationale: Arterial thrombi typically form at sites of disrupted atherosclerotic plaques. Endothelial injury directly exposes prothrombotic subendothelial collagen and tissue factor, triggering platelet adhesion/aggregation and coagulation activation.

2. Venous Thrombosis (e.g., DVT)

Correct Answer: [a) Alteration in Blood Flow] or [b) Hypercoagulability]

Rationale: Venous thrombi often arise from stasis (e.g., immobility) or hypercoagulable states (e.g., Factor V Leiden). If forced to choose one, prioritize [a) Alteration in Blood Flow] as stasis is the most common trigger.

Why Not Other Options?

[d) Fatty Streak] is incorrect because it represents early atherosclerosis, not active thrombosis.

Note: In practice, all three Virchow triad components (a/b/c) contribute, but exam questions often focus on the most context-specific factor.

Exam Strategy:

If the question mentions "myocardial infarction" or "artery", choose c.

If it refers to "DVT", "surgery", or "immobility", choose a.

If genetic clotting disorders (e.g., Leiden mutation) are explicitly mentioned, choose b.