MCQs on Diseases of Blood - RBC Disorders, WBC disorders, Bleeding / Clotting Disorders

# All of the following statements about idiopathic thrombocytopenic purpura are true EXCEPT :
A. It is associated with platelet-specific auto-antibodies
B. It causes a prolonged bleeding time
C. It is often controllable by immunosuppressive treatment
D. It causes more prolonged hemorrhage than hemophilia

# The oral findings in erythroblastosis fetalis include:
A. Dentinal Dysplasia
B. Hypoplastic teeth
C. Pigmented teeth
D. All of the above

# The red blood cells in beta thalassemia are typically:
A. macrocytic and normochromic
B. microcytic and hypochromic
C. normocytic and hypochromic
D. normocytic and normochromic

# "Hair-on-end" appearance in a skull radiograph is seen in:
A. Fibrous dysplasia
B. Thalassemia
C. Garre's Osteomyelitis
D. Paget's disease

# Which of the following is not a finding in classical hemophilia (hemophilia A) ?
A. Bleeding into soft tissues, muscles and joints
B. Decreased factor VIII
C. Increased prothrombin time
D. Increased partial thromboplastin time

# Neurological symptoms and premature graying of hair is associated with:
A. Folic acid deficiency
B. Pernicious anemia
C. Plummer-Vinson syndrome
D. Paterson-Kelly Syndrome

# Which of the following is seen in idiopathic thrombocytopenic purpura?
A. Thrombocytosis
B. Increased prothrombin time
C. Increased bleeding time
D. Increased clotting time

# Which of the following disease is known as the " kissing disease" ?
A. Acquired immunodeficiency syndrome
B. Infectious mononucleosis
C. Primary syphilis
D. Recurrent aphthous stomatitis

# To prevent excessive bleeding during surgery a patient with hemophilia A may be given:
A. Whole blood
B. Fresh frozen plasma
C. Factor VIII concentrate
D. Factor IX concentrate

# Hemophilia B is due to:
A. Factor VII deficiency
B. Factor IX deficiency
C. Platelet deficiency
D. Vit C deficiency

# Paul Bunnel test is positive in:
A. Infectious mononucleosis
B. Multiple myeloma
C. Malignant nerves
D. RUbella

# A young patient is hospitalized with petechiae of oral mucous membrane, marginal gingival hemorrhage and with a platelet count of 45000/cc. The BT and clot retraction time are increased, RBC and TLC are normal. He is suffering from:
A. Infectious mononucleosis
B. Thrombocytopenic purpura
C. Leukemia
D. Hemophilia

# Pinpoint hemorrhage of less than 1cm diameter are known as:
A. Petechiae
B. Ecchymoses
C. Purpura
D. Pustules

# Which of the following agents is of value in the postoperative care of the hemophilic patient?
A. Vitamin K
B. Monsel's solution
C. Aminocaproic acid
D. Factor 8 cryoprecipitate

# Pernicious anemia is:
A. insufficient production of red cells
B. improper maturation of red cells
C. can be corrected by tablets of folic acid alone
D. can be corrected by iron supplement

# Which of the following is not associated with hemorrhage ?
A. Ecchymosis
B. Petechiae
C. Melanosis
D. Purpura

# Necrotising ragged ulceration with no apparent inflammatory response is indicative of :
A. Leucocytosis
B. Polycythemia vera
C. Sickle cell anemia
D. Agranulocytosis

# Leucocytopenia is seen in:
A. Influenza
B. Agranulocytosis
C. Liver cirrhosis
D. All of the above

# Bleeding time is prolongd in:
A. Haemophilia
B. Von willebrand's disease
C. Henoch Schenolein purpura
D. Telangiectasia

# Clinical features of infectious mononucleosis:
A. Glandular involvement
B. Febrile
C. Palatine petechiae
D. All of the above
# Petechial hemorrhage is seen in :
A. cyclic neutropenia
B. agranulocytosis
C. pernicious anemia
D. thrombocytopenic purpura

# Christmas disease is due to deficiency of:
A. Hageman Factor
B. Platelets
C. Plasma Thromboplastin antecedent
D. Plasma Thromboplastin component

# A boy complains of bleeding gums, swollen joints with hemorrhage into joints. His paternal and maternal uncle also had the same problem. It is due to deficiency of factor:
C. X

# Common oral change seen with nutritional anemia is:
A. Enlarged tongue
B. Atrophic glossitis
C. Generalized Osteolysis
D. Focal marrow expansion

# Hypopigmentation, gray streaks of hair, degranulation defect of neutrophils and neuropathy are seen in:
A. Aleukemic leukemia
B. Chronic granulocytic leukemia
C. Lazy leukocyte syndrome
D. Chediak Higashi syndrome

# Chronic granulocytic leukemia is due to:
A. Chromosomal deletion
B. Chromosomal mutation
C. Chromosomal translocation
D. None of the above

# Bleeding joints is a characteristic feature of:
A. Vit-C deficiency
B. Hemophilia
C. Vit-K deficiency
D. Thrombocytopenia

# Plummer-Vinson syndrome:
A. is due to Folic acid deficiency
B. common in males
C. not associated with oral malignancy
D. strong association with post-cricoid carcinoma

# Patient giving history of thrombocytopenic purpura reports for extraction. What could be the most common postoperative complication ?
A. Oedema
B. Haemorrhage
C. Infection spreading through tissue spaces
D. Dry socket

# For extraction in a leukemic patient:
A. consult physician
B. obtain WBC count
C. Obtain platelet count
D. all of the above

# All of the following statements about acute leukemia in children are true EXCEPT:
A. It characteristically causes gross gingival swelling
B. It may be manifested by mucosal pallor
C. It can cause obvious purpura
D. It is usually of the lymphoblastic variety

# Which of the following is the most serious and life threatening blood dyscrasia caused by a drug?
A. Aplastic anemia
B. Megaloblastic anemia
C. Thrombocytopenia
D. Hemolytic anemia

# Monospot test is used to diagnose:
A. Pernicious anemia
B. Sickle cell anemia
C. Infectious mononucleosis
D. Leukemia

# Precancerous potential in Plummer-Vinson's syndrome may be due to change in the epithelium like:
A. Atrophy
B. Hypertrophy
C. Acanthosis
D. All of the above

# Infectious mononucleosis has:
A. Multiple draining sinuses
B. Ulcers which bruise easily
C. Palatal perforation
D. Alveolar bone loss

# Chemotherapy can be successful during the treatment of :
A. Ameloblastoma
B. Leukemia
C. Fibrosarcoma
D. Basal cell carcinoma

# Virus responsible for infectious mononucleosis is:
A. RNA paramyxo virus
B. Varicella zoster virus
C. Epstein Barr virus
D. Coxsackie virus A 16

# Oral manifestations of infectious mononucleosis is most commonly:
A. Bluish red spots opposite maxillary molar
B. Pseudomembrane on gingiva
C. Pinpoint petechiae on the palate
D. Gingival hyperplasia

# Megaloblastic anemia occurs due to:
A. Iron deficiency
B. Folate deficiency
C. Vitamin C deficiency
D. Protein deficiency

# One of the following syndrome is characterized by an esophageal web with resulting dysphagia, atrophic changes in the mucous membranes of the mouth and a hypochromic microcytic anemia:
A. Marfan's syndrome
B. Plummer-Vinson's syndrome
C. Meckels syndrome
D. Sjogren's syndrome

# Aplastic anemia is common with:
A. Chloramphenicol
B. Cephalosporin
C. Tetracycline
D. Penicillin

# Hemophilia is associated with:
A. Normal bleeding time, normal clotting time
B. Normal bleeding time, prolonged clotting time
C. Prolonged bleeding time, normal clotting time
D. Prolonged bleding time, prolonged clotting time

# Which of the following is sex linked disorder ?
A. Thalassemia
B. Klinefelter's syndrome
C. Hemophilia
D. Neurofibromatosis

# A hair-on-end appearance of the skull is seen in all of the following except:
A. Thalassemia
B. Sickle cell anemia
C. Cooley's anemia
D. Paget's disease
# A patient on warfarin sodium following myocardial infarction reports for an oral surgical procedure. Which of the following lab tests should be preferred to ascertain the fitness?
A. Prothrombin time
B. Torniquet time
C. Clotting time
D. Bleeding time

# Which one of the following is not true about thalassemia ?
A. Increase in number of globulin chain
B. There is erythrocyte fragility and hemolysis
C. Hypochromic microcytic anemia is present
D. There is severe anemia and thrombocytopenia

# Erythroblastosis fetalis can be prevented if the mother is injected at parturition, with an antibody called:
A. Blocking antibody
B. Rh(D) immunoglobulin
C. Antilymphocyte globulin
D. Antithymocyte serum

# Deficiency of all the three components of coagulation factor VIII results in:
A. Von Willebrand's disease
B. Haemophilia A
C. Parahemophilia
D. Haemophilia B

# Cooley's anemia is also known as:
A. Erythroblastosis Foetalis
B. Aplastic anemia
C. Thalassemia
D. Pernicious anemia

# The most striking hematological finding in agranulocytosis is:
A. Decreased absolute neutrophil count
B. Increased absolute eosinophil count
C. Decreased absolute basophil count
D. Increased absolute monocyte count

# The most common coagulation disorders hemophilia A and von Willebrand's disease are due to:
A. Factor IX deficiency
B. Vitamin K deficiency
C. Factor X deficiency
D. Factor VIII deficiency

# In radionuclide imaging, the most useful radiopharmaceutical for skeletal imaging is:
A. Gallium 67 (67 Ga)
B. Technetium - 99m (99m Tc-Sc)
C. Technetium - 99m (99m Tc)
D. Technetium - 99m linked to methylene disphosphonate (99m Tc-MDP)

# The most reliable criteria in Gustafson's method of identification is:
A. Cementum apposition
B. Transparency of root
C. Attrition
D. Root resorption

# Which of the following blood disease has a racial predilection ?
A. Purpura
B. Hemophilia
C. Polycythemia
D. Thalassemia

# All of the following are true in Immune thrombocytopenic purpura (ITP) EXCEPT:
A. Chronic ITP commonly occur in adult women
B. Associated with normal bleeding time
C. Prothrombin time (PT) and Partial thromboplastin time (PTT) are normal
D. Increased megakaryocytes in bone marrow

# Chediak-Higashi Syndrome is inherited as:
A. X linked dominant trait
B. Autosomal dominant
C. Autosomal recessive
D. X linked recessive

# Commonest mode of inheritance in Von-Willebrand's disease is:
A. Co-dominant
B. Autosomal dominant
C. Autosomal recessive
D. X linked recessive

# Patient has increased PT, APTT & TT and normal fibrinogen and platelets counts. The diagnosis is:
B. Factor VIII deficiency
C. Liver disease
D. Vitamin K deficiency

# Agent responsible for increasing factor VIII activity in hemophilia is:
A. Epsilon aminocaproic acid
B. Tranexamic acid
C. Avitene
D. Deamino D Arginine vasopressin