MCQs on Skin and Vesiculobullous Diseases - Oral Pathology and Medicine MCQs

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# A flat, circumscribed discoloration of skin or mucosa that may vary in size and shape is referred to as: (MAN -94,95; AP- 08)
a) Epulis
b) Macule
c) Nodule
d) Papule

# A twenty-one-year-old woman complains that regular, gentle brushing of her teeth is painful besides causing profuse bleeding. Oral examination reveals the loss of epithelium from the attached gingiva of both arches. Which of the following dermatological problems is this patient most likely to have? (MAN -95)
a) Benign mucous membrane pemphigoid
b) Chronic discoid lupus erythematosus
c) Pemphigus
d) Psoriasis

# Which of the following is an oral manifestation of lichen planus? (MAN -95)
a) Dentinogenesis imperfecta
b) Fordyce spots
c) White, chalky enamel surface
d) White radiating lines on the buccal mucosa

# Antinuclear antibodies are seen in: (MAN -98, KCET -07)
a) SLE
b) Systemic sclerosis
c) Morphea
d) All of the above

# Which of the following diseases of the skin is the most likely to be associated with partial anodontia? (MAN -98, KAR -03)
a) erythema multiforme
b) hereditary ectodermal dysplasia
c) keratosis follicularis
d) lichen planus

# Which of the following is absent in CREST syndrome? (KAR -03, PGI -99, MAN -2K)
a) Calcinosis cutis
b) Raynaud's phenomenon
c) Telangiectasia
d) Endocrine disorders

# Nikolsky's sign is positive in: (KAR -03, COMEDK -03)
a) bullous pemphigus
b) epidermolysis bullosa
c) herpes simplex
d) erythema multiforme

# MONRO's abscess are seen in: (MAN -2K, KAR -97,98)
a) Pemphigus
b) Lichen planus
c) Leukoplakia
d) Psoriasis

#  In lichen planus the basal cells which are shrunken with an eosinophilic cytoplasm and with a pyknotic and fragmented nuclei are called: (MAN -01)
a) Tzanck cells
b) Civatte bodies
c) Donovan bodies
d) Rushton bodies

# Grinspan syndrome is associated with: (COMEDK -03, 06, KAR-04)
a) Hypertension, diabetes, lichen planus
b) Oral, ocular, genital lesions
c) Hypertension with oral lesions
d) Pemphigus, CHF, diabetes

# Ectodermal dysplasia is: (AIPG-05)
a) Autosomal recessive
b) Autosomal dominant
c) X-linked dominant
d) X-linked recessive

# Which sites are characteristically affected in Stevens- Johnson syndrome? (APPSC -99)
a) Conjunctiva, genitalia, oral mucosa
b) Liver, spleen, pancreas
c) Oral mucosa, lacrimal apparatus, ears
d) Parotid gland, palate, conjunctiva

# Which one of the following is NOT a lichenoid reaction? (COMEDK-14)
a) Graft versus Host disease
b) Fixed drug eruption
c) Secondary syphilis
d) Pemphigus vulgaris

# Oral diagnostic features of scleroderma include all of the following, except: (KAR -2K)
a) Pseudo ankylosis of the T.M. Joint
b) Widening of the oral aperture
c) A hard and a rigid tongue
d) Difficulty in swallowing

# A typical example of an immunologically mediated collagen vascular/connective tissue disorder is: (MCET-14)
a) Lichen planus
b) Pemphigus vulgaris
c) Lupus erythematosus
d) Epidermolysis bullosa

# Fine Needle aspiration biopsy is indicated to diagnose: (KAR -98)
a) Necrotic pulp
b) Pemphigus
c) Traumatic ulcer
d) Chronic gingivitis

# Subepithelial vesicles are characteristic all of the following EXCEPT: (KCET-08)
a) Bullous pemphigoid
b) Pemphigus
c) Epidermolysis bullosa acquisita
d) Cicatricial pemphigoid

# Which is a degeneration disorder characterized by atrophic changes of the deeper structures (e.g. fat, muscle, cartilage & bone) involving one side of the face: (AIPG -04, 05)
a) Miescheris syndrome
b) Peutz-Jeghers syndrome
c) Parry Romberg syndrome
d) Scleroderma

# In Cicatrial pemphigoid, which antigen is bound by IgG on the epidermal side of the salt split skin technique: (COMEDK-07)
a) Laminin 5
b) XVII collagen
c) epitigrin
d) BP antigen 1 & 2

# L.E. Cell phenomenon in peripheral blood is seen in: (KAR -2K)
a) Systemic Lupus Erythematosus
b) Ischemic heart disease
c) Infective endocarditis
d) Rheumatic heart disease

#  Erosive lichen planus resembles which of the following: (AIIMS -2K)
a) Monilial gingivitis
b) Acute ulcerative gingivitis
c) Desquamative gingivitis
d) Herpetic gingivitis

# Grinspan syndrome is associated with: (KAR-04)
a) Lichen planus
b) Aphthous ulcer
c) Leukoplakia
d) Oral submucous fibrosis

# Desmoplakin is the target antigen in: (AP-2012)
a) Pemphigus foliaceous
b) Pemphigus Vulgaris
c) Drug-induced pemphigus
d) Paraneoplastic pemphigus

# Unusual extensibility of the tongue is a characteristic feature of: (KAR -03)
a) Syphilis
b) Darier-White disease
c) Ehlers-Danlos syndrome
d) Epidermolysis bullosa

# 60 year old diabetic female presented with burning sensation to spicy food, Intraoral examination revealed multiple periodontal abscess and keratotic area in a lace pattern with occasional erosive areas inside the lace pattern. Syndrome associated with this disease is: (COMEDK-14)
a) Peutz jeghers syndrome
b) Sjogren's syndrome
c) Down's syndrome
d) Grinspan syndrome

# En coup de sabre is most likely to be associated with which type of scleroderma?
a) Linear
b) Radicular
c) Vertical
d) Ovoid

# Histopathologic study of lichen planus shows: (AIIMS-99,94; KAR-98)
a) Antiepithelial antibodies
b) Scattered infiltrate with ill-defined lower border
c) Mixed cellular inflammatory infiltrate
d) Presence of T-lymphocytes predominantly

# Cafe au lait macules are seen in: (KCET-10)
a) Albright's syndrome and Bloom's syndrome
b) Von Reklinghausen's neurofibromatosis
c) None of them
d) All of them

# Psoriasis is associated with: (PGI -95)
a) Lupus erythematosus
b) Lupus vulgaris
c) Benign median rhomboid glossitis
d) Geographic tongue

# White radiating lines can be observed in case of lesions of: (AP -2K, AIIMS MAY -2012)
a) Erythema multiforme
b) Lichen planus
c) Pemphigus
d) Leukoplakia

#  Pemphigus is characterized by: (AIPG -94, 06)
a) Hyperparakeratosis
b) Hyperorthokeratosis
c) Acantholysis
d) Acanthosis

# 60 year old diabetic female presented with burning sensation to spicy food. Intraoral examination revealed multiple periodontal abscess and keratotic area in a lace pattern with occasional erosive areas inside the lace pattern. Histological feature will be: (COMEDK-14)
a) Saw tooth rete ridges
b) Bulbous rete ridges
c) Elongated rete ridges
d) Flattened rete ridges

# Mucocutaneous lesion associated with neoplasia : (COMEDK-2011)
a) Paraneoplastic pemphigus
b) Parapemphigus
c) Pemphigus vegetans
d) Familial benign pemphigus

# ALL the following are inherited disorders of connective tissue EXCEPT: (KAR- 2013)
a) Marfan syndrome
b) McArdle's disease
c) Ehlers-Danlos syndrome
d) Alport syndrome

# Cicatrical pemphigoid is the synonym for: (AP-2012)
a) pemphigus vulgaris
b) mucous membrane pemphigoid
c) paraneoplastic pemphigus
d) Hailey-Hailey disease

# Pathologic calcification is seen in: (COMEDK-09)
a) Scleroderma
b) Lupus erythematosus
c) Dystrophic epidermolysis bullosa
d) Lichen planus

# A 3-year-old patient has extensive vesicles on lip, tongue, oral mucous membrane. After 2-4 days vesicles rupture at followed by pseudomembrane formation and also some dermal lesions seen what will be the diagnosis: 
a) Steven-Johnson syndrome
b) Herpetic stomatitis
d) EM

# Oral, ocular and genital lesions are seen in: (AP -04)
a) Erythema multiforme
b) SLE
c) Stevens-Johnson syndrome
d) None of them

#  Tzanck smear test is used in the diagnosis of: (KAR -02)
a) Pemphigus
c) Lichen planus
d) Apthous disease

# Multiple pulp stones are seen in: (COMEDK-10)
a) Down's syndrome
b) Ehler's Danlos syndrome
c) Apert's syndrome
d) Marfan Syndrome

# Erythema multiforme is: (KAR -97)
a) Bacterial infection
b) An acute self-limiting disease, of skin and oral mucous membrane
c) Painless vesicular self-limiting disease
d) A viral disease

# Target Lesions are observed in case of: (COMEDK -03, 06; AP -2K)
a) Erythema multiforme
b) Psoriasis
c) Lichen planus
d) Pemphigus vulgaris

# Lupus erythematosus is: (KAR -03)
a) Autoimmune disorder
b) Neoplastic condition
c) Degenerative condition
d) Reactive Lesion

# Oral Lesions are not seen in: (AP -04)
a) Psoriasis
b) Pemphigoid
c) Candidiasis
d) Stevens-Johnson syndrome

# False about mucous-membrane pemphigoid: (PGI-2014)
a) Twice in female
b) Disease associated antigen are most frequently present in lamina densa
c) Oral mucosa is most frequently involved
d) Autoantibodies towards basement membrane protein

# The swollen degenerating epithelial cell due to acantholysis is: (KAR-04)
a) Tzanck cell
b) Prickle cell
c) Anitschow cell
d) Ghost cell

# Primary lesion in lichen planus is: (KAR -97)
a) Bulla
b) Vesicle
c) Papule
d) Macule

# Koebner's phenomenon is seen with: (KAR -02)
a) Psoriasis
b) Erythema muLtiforme
c) Impetigo
d) Pemphigoid

# Which of the following is inherited as an autosomal dominant trait? (KAR -98rAIIMS -94)
a) Bullous pemphigoid
b) White sponge nevus
c) Lichen planus
d) Pemphigus vulgaris

# Wickham's striae are seen in: (AP -03}
a) Leukoedema
b) Erythema multiforme
c) Lichen planus
d) Leukoplakia

# In ectodermal dysplasia all of the following structures are affected except: (AIPG -94)
a) Teeth
b) Salivary glands
c) Nails
d) Hair

# Ehlers Danlos syndrome is? (AIPG-09)
a) X-Linked recessive
b) X-Linked Dominant
c) Autosomal recessive
d) Autosomal Dominant

# Butterfly rash is typically seen in: (KCET-10)
a) Systemic lupus erythematosus
b) Herpes simplex
c) Scleroderma
d) None of them

#  Joint erosions are not a feature of:  (AIPG-06)
a) Rheumatoid arthritis
b) Multicentric reticulo-histiocytosis
c) Systemic Lupus eythematosus
d) Psoriasis

# Xeroderma pigmentosum is characterized by: (COMED-2012)
a) Autosomal dominant inheritance
b) Inability to repair sunlight induced damage to DNA
c) Acanthosis of epithelium with elongation of rete ridges
d) Irregular accumulation of melanin in the basal cell layer

# All are diseases of skin except: (AIIMS-09)
a) Keratosis follicularis
b) Erythema multiforme
c) Psoriasis form lesion
d) Erythema migrans

# Intraepithelial vacuolation with formation of vesicle or bulla intraepithelially above the basal layer is characteristically seen in: (AIPG -95)
a) Pemphigus
b) Lichen planus
c) Bullous pemphigoid
d) Candida albicans

# Darier's disease is associated with: (AIPG -04)
a) Vitamin A deficiency and involvement of oral epithelium and skin
b) Diffuse tender ulceration on the palate predominantly
c) Pernicious anaemia
d) Rickets with involvement of teeth and bones

# Which of the following individual show susceptibility to dental caries? (PGI DEC-2013)
a) Down syndrome
b) Pierre robin syndrome
c) Epidermolysis bullosa
d) Hereditary fructose intolerance

# Which of the following is not a type of lichen planus? (KAR -03)
a) Hypertrophic
b) Atrophic
c) Verrucous
d) Erosive

# Autoantibodies Anti Ro and Anti La are completely absent in: (COMEDK-15)
a) Sjogren's syndrome
b) Diffuse Scleroderma
c) Rheumatoid arthritis
d) Systemic lupus erythematosus

# Immunoflourescence is seen at basement membrane as patchy distribution in: (KAR -97)
a) Lichen Planus
b) Pemphigus
c) Pemphigoid
d) Lupus erythematosus

# Histological clefts in lichen planus are: (COMEDK-09)
a) Auspitz's sign
b) Civatte bodies
c) Wickham's Striae
d) Max - Joseph spaces

#  Most common lesion in Mucous membrane pemphigoid is: (COMEDK-14)
a) Esophageal ulcer
b) Ulcer of Soft palate
c) Symblepharon
d) Desquamative gingivitis

# Which of the following are seen in ectodermal dysplasia? (AIIMS -90}
a) Defective or absence of sweat glands
b) Hyperpyrexia
c) Protuberant lips and frontal bossing
d) Any of them

# In which of the following disorders a circulating antibody directed to intercellular cementing substance of stratified squamous epithelium is observed: (AIIMS, KAR -03)
a) Pemphigus vulgaris
b) Bullous pemphigoid
c) Verrucous vulgaris
d) Lichen planus

# Fish Net pattern in pemphigus vulgaris is seen in which of the following tests? (KAR-2013)
a) Tzanck smear
b) Histopathology
c) Direct immunofluorescence

# Intra-epithelial bulla are found in: (AIIMS-98)
a) Pemphigoid
b) Pemphigus
c) Bullous pemphigoid
d) Bullous lichen planus

# A 60-year-old has got severe bulla and target lesion which erythema around halo and genital Lesions: (AIIMS -2K)
a) Herpes zoster
b) Stevens Johnson syndrome
c) Herpes simplex
d) Herpangina

# Bullae formation after striking an intact skin/mucosal surface is known as: (KAR -2K)
a) Chovstek's sign
b) Tinel's sign
c) Babinski's sign
d) Nikolsky's sign

# Hydropic degeneration of the basal cell of the stratum germinativum is a feature of? (PGI-08)
a) Leukoplakia
b) Lichen Planus
c) Pemphigus
d) Syphilis

# Steven-Johnson syndrome involves: (AIPG -98)
a) Type I hypersensitivity reaction
b) Type IV hypersensitivity reaction
c) Type II hypersensitivity reaction
d) Type III hypersensitivity reaction

# Lichen planus: (KAR -02)
a) Must be excised
b) Treated only by medication
c) Can undergo malignant change
d) Is an idiosyncrasy reaction

# Oral lesion associated with ulcerative colitis: (COMEDK-10)
a) Pyostomatitis Vegetans
b) Sarcoidosis
c) Lichen planus
d) Dermatitis herpetiformis

# Immunoflourescence test is positive in: (AIPG -95)
a) Psoriasis
b) Lupus erythematosus
c) Scleroderma
d) Myxoedema

# Formation of multiple pinpoint bleeding spots on scratching the skin is characteristic of: (KAR -2K)
a) Pemphigus vulgaris
b) Lupus erythematosus
c) Psoriasis
d) Herpangina

# Lichenoid reactions are mainly due to: (AP-99)
a) intake of alcohol
b) cigarette smoking
c) betel nut chewing
d) intake of certain drugs

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