BPKIHS First Year BDS past Question- UNIT 1 - March 2014

21st MAR 2014

B.P. Koirala Institute of Health Sciences, Dharan, Nepal
1st year BDS
Internal Assessment Examination, March 2014
Paper - II A

(GENETICS, GROWTH AND DEVELOPMENT, IMMUNOLOGY & BLOOD)

Time - 2 Hours
 Total Marks: 125
SHORT ANSWER QUESTIONS

SECTION - 'A'

ANATOMY 
1. Classify chromosomal disorders with examples of each.                        5
2. Draw a labeled histological diagram of lymph node.                              5
3. Write the criteria and examples of X-linked recessive disorder.             5


                                                                    SECTION - 'B'
PHYSIOLOGY

4. State Landsteiner's law. Explain Rh and ABO blood group on the basis of this law.      2+2=4
5. With the help of flow diagram, explain the extrinsic pathway in blood coagulation.      4
6. Explain the role of erythropoietin in red blood cells production.       4
7. Draw the general, somatic and neural growth curves and briefly compare their patterns.     4
8. Explain the role of cytotoxic T cell in cellular immunity.              4



SECTION 'C'
BIOCHEMISTRY
9. Define the terms isotypes, idiotypes and allotypes.  Draw a labeled diagram of immunoglobulin.      3+2=5
10. Write similarities and differences between the processes of DNA and RNA synthesis.      5
11. Enumerate different post-translational modifications of polypeptide chain. Explain the function of chaperones.              3+2=5
12. Describe the mechanism of gene regulation with the help of lac operon model.          5
13. Explain how polymerase chain reaction (PCR) helps to amplify a target sequence of DNA.     5
14. Explain with a diagram mechanism of  iron absorption in the intestine.         5


SECTION 'D'
PATHOLOGY
15. Enumerate the types of Hypersensitivity reactions. Give at least two examples for each. Write briefly about type II hypersensitivity reaction.          2+1+2=5
16. Enumerate the types of blood components. What are the immediate and delayed blood transfusion reactions.         2+4 =6
17. Describe the peripheral smear and bone marrow findings of Megaloblastic anemia.     5+3=8
18. Enumerate six differences between AML and ALL.                                                     6
19. Classify Hemolytic Anaemia.                                                                                        5


SECTION 'E' 

MICROBIOLOGY
20. Draw a labeled diagram of HIV.                           5
21. Write short note on innate immunity.                   5
22. List the fungi causing opportunistic infection. Add a note on approach to lab diagnosis of any one of them.       2+3=5 


SECTION 'F'
PHARMACOLOGY
23. Explain warfarin effect in pregnancy.                 5
24. Explain Cyclophosphamide effect in urinary bladder.        5
25. Explain Cyclosporine effect in kidney.                               5


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