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Which has common role in osteoblast, fibroblast and cementoblast?

 # Which has common role in osteoblast, fibroblast and cementoblast?
A. Osteopontin
B. Osteocalcin
C. Osteogenin
D. Bone Sialoprotein



The correct answer is A. Osteopontin.

Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. 

Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). 

Osteopontin is biosynthesized by a variety of tissue types including fibroblasts preosteoblasts, osteoblasts, osteocytes, odontoblasts, some bone marrow cells, hypertrophic chondrocytes, dendritic cells, macrophages, smooth muscle, skeletal muscle myoblasts, endothelial cells and extraosseous (non-bone) cells in the inner ear, brain, kidney, deciduum and placenta. 


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