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The gene aberrant in dentinogenesis imperfecta is:

 # The gene aberrant in dentinogenesis imperfecta is:
A. Chromosome 4
B. Chromosome 13
C. Chromosome 21
D. Chromosome 24



The correct answer is A. Chromosome 4.

Aberration in chromosome 4 (4q21.3) is associated with Dentinogenesis imperfecta. It encodes dentin specific sialophosphoprotein (DSPP) gene. Deficiency of sialoprotein is also suggested as a causative factor for DI. They are generally tulip shaped. 

Chromosome number              Disease 
1                                               Vanderwoude syndrome
4                                               Dentinogenesis Imperfecta 
4                                               Cherubism
15                                             Marfan's syndrome
19                                             Osteogenesis imperfecta

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