Enzyme marker of acute alcohol toxicity

 # A person with a long history of alcohol intake reports with acute alcohol intoxication. Which of the following enzymes is a marker of acute toxicity?

A. AST

B. ALT

C. GGT

D. Alkaline phosphatase

The correct answer is:

C. GGT (Gamma-Glutamyl Transferase)

Explanation:
Gamma-glutamyl transferase (GGT) is a sensitive marker for alcohol consumption and acute alcohol toxicity. It is elevated in conditions involving liver damage, particularly from chronic alcohol use. While AST and ALT may also be elevated in liver damage, GGT is more specific for alcohol-related effects. Alkaline phosphatase is primarily associated with biliary obstruction or bone disorders.