# Enlarged, grayish yellow or orange tonsils are pathognomic of ? A. Waldenström’s macroglobulinemia B. Polycythemia vera C. Wolman disease D. Tangier disease The correct answer is D. Tangier Disease. Tangier disease is associated with cholesterol accumulation in reticuloendothelial system with hepatosplenomegaly & enlarged, grayish yellow or orange tonsils. Ref: Harrison’s 18th Ed. 3154