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Dentigerous Cyst / Follicular Cyst

Dentigerous Cyst
  • defined as an odontogenic cyst that surrounds the crown of an impacted tooth; caused by fluid accumulation between the reduced enamel epithelium and the enamel surface, resulting in a cyst in which the crown is located within the lumen.
  • most common ; about 20% of all jaw cysts ; about 10% of impacted tooth form a dentigerous cyst
  • almost always permanent tooth involved; rarely deciduous tooth involved
Clinical Features:
  • always associated initially with the crown of an impacted, embedded or unerupted tooth
  • most common sites of this cyst are the mandibular and maxillary third molar and maxillary cuspid areas, as these teeth are most commonly impacted
  • mostly solitary; bilateral and multiple cysts are usually found in association with a number of syndromes including cleidocranial dysplasia and Maroteaux–Lamy syndrome.
  • potentially agressive; due to continuous enlargement of the cyst, may result in expansion of bone with subsequent facial asymmetry, extreme displacement of teeth, severe root resorption of adjacent teeth and pain
  • usually, no pain or discomfort associated with the cyst unless it becomes secondarily infected
Radiographic Features
  • radiolucency associated in some fashion with an unerupted tooth crown is observed
  • may be confused with the enlarged dental follicle; histologically identical
  • normal follicular space is 3–4 mm, a dentigerous cyst can be suspected when the space is more than 5 mm
Three radiological variations may be observed:
Central - crown is enveloped symmetrically
Lateral - results from dilatation of the follicle on one aspect of the crown
Circumferential - results when the follicle expands in a manner in which the entire tooth appears to be enveloped by the cyst

Histologic Features
  • no characteristic microscopic features which can be used reliably to distinguish the dentigerous cyst from the other types of odontogenic cysts
  • usually composed of a thin connective tissue wall with a thin layer of stratified squamous epithelium lining the lumen
  • unless secondarily infected, rete pegs are absent
  • varying numbers of islands of odontogenic epithelium seen ( also seen in normal dental follicles )
  • inflammatory cell infiltration of the connective tissue is common
  • in cysts exhibiting inflammation, Rushton bodies, which are peculiar linear, often curved, hyaline bodies with variable stainability which are of uncertain origin, questionable nature and unknown significance, are seen within the lining epithelium
  • content of the cyst lumen is usually a thin, watery yellow fluid, occasionally blood tinged

Treatment
  • depends upon the size of the lesion - smaller lesions totally removed surgically, larger cysts are often treated by insertion of a surgical drain or marsupialization as larger cysts involve serious loss of bone and there is potential of fracturing the jaw if complete surgical removal is attempted
  • recurrence relatively uncommon
Potential complications
Besides recurrence, following complications may occur:
  • development of an ameloblastoma
  • development of epidermoid carcinoma
  • development of a mucoepidermoid


MCQs on Cardiovascular System - Physiology Part 2


# Absolute period when whole heart is in diastole is :
A. 0.7 sec
B. 0.3 sec
C. 0.2 sec
D. 0.4 sec

# The effects of adrenaline on heart are all except :
A. Increases heart rate
B. Decreases myocardial irritability
C. Increases force of contraction
D. Increases oxygen uptake by heart

# Cardiac output is maximum to :
A. Liver
B. Brain
C. Kidney
D. Heart

# Increase in carotid sinus pressure produces:
A. Reflex hyperpnea
B. Reflex bradycardia
C. Reflex tachycardia
D. Reflex hypercapnia

# Effect on force of contraction of heart is :
A. Chronotropic effect
B. Dromotropic efffect
C. Bathmotropic effect
D. Inotropic effect

# SA node acts as a pacemaker of the heart because of the fact that it:
A. is capable of generating impulses
B. has rich sympathetic innervations
C. has poor cholinergic innervations
D. generates impulses at the highest rate

# Distribution of blood flow is mainly regulated by the :
A. Arteries
B. Arterioles
C. Capillaries
D. Venules

# The following factors increase the cardiac output except:
A. Preload
B. Afterload
C. Heart rate
D. Myocardial contractility

# Ventricular muscle receives impulses directly from the:
A. Purkinje system
B. Bundle of His
C. Right and left bundle branches
D. AV node

# In determining blood pressure by auscultatory method,
A. The loudest sound is the diastolic pressure
B. Systolic pressure estimation tends to be lower than those made by palpatory method
C. The first sound heard is systolic pressure
D. The sounds that are heard are generated in heart

# Isovolumetric relaxation ends immediately after:
A. AV valve closes
B. When ventricular pressure falls below aortic pressure
C. When ventricular pressure falls below atrial pressure
D. None of the above

# Glomerular capillary pressure differ from other capillaries of body in:
A. Higher filtration pressure
B. Lower filtration pressure
C. Both of the above
D. None

# The hemoglobin oxygen saturation of blood entering the right ventricle is approximately:
A. 97 percent
B. 85 percent
C. 75 percent
D. 53 percent

# Which of the following increases turbulence in blood flow ?
A. Reynolds number <2000
B. Decrease in viscosity of blood
C. Decrease in density of blood
D. Increase in diameter of blood vessel
# In the case of heart muscle , all are true except:
A. Acts as syncytium
B. Has multiple nuclei
C. has gap junctions
D. has branching

# The velocity of conduction in the purkinje fibers of the heart is :
A. 1 to 4 m/s
B. 5 to 8 m/s
C. 9 to 12 m/s
D. more than 12 m/s

# Second heart sound is characterized by all except:
A. due to closure of semilunar valves
B. is occasionally split
C. has longer duration than first heart sound
D. marks the onset of diastole

# What is common between systemic and pulmonary circulation?
A. Volume of the circulation per minute
B. Peripheral vascular resistance
C. Pulse pressure
D. Total capacity

# Stimulation of the baroreceptors results in :
A. Increase in heart rate
B. Decreased vagal discharge
C. Increased sympathetic discharge
D. Decrease in blood pressure

# The function of carotid body is :
A. Measures the change in pO2 in arterial blood
B. Measures pO2 in venous blood
C. Measures the change in CO2 in arterial blood
D. Measures the change in CO2 in venous blood

# The dicrotic notch on the aortic pressure curve is caused by :
A. Closure of the pulmonary valve
B. Rapid filling of the left ventricle
C. Closure of the aortic valve
D. Contraction of the aorta

# Peripheral vascular resistance is best given by :
A. Mean arterial pressure responsible for blood flow to organ
B. Diastolic blood pressure as it decreases till mid-thoracic aorta
C. Pulse pressure as it relates to stroke volume and aortic compliance
D. Systolic pressure as it increase in descending aorta

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MCQs on Cardiovascular System - Physiology

# The first heart sound is produced by the :
A. Closure of the aortic and pulmonary valves
B. Opening of the aortic and pulmonary valves
C. Closure of the mitral and tricuspid valves
D. Opening of the mitral and tricuspid valves


# Parasympathetic stimulation of heart causes:
A. SA node decreases firing
B. Increased AV node excitability
C. Decreased ventricular contraction
D. Tachycardia

# Normally, the rate of the heart beat in a human is determined by:
A. Bundle of His
B. all cardiac muscles
C. the SA node
D. the cervical ganglion

# The ventricular repolarisation in ECG is best seen in:
A. "P" wave
B. "Q" wave
C. "R" wave
D. "T" wave

# Stroke output of each ventricle in normal adult is :
A. 30 ml
B. 130 ml
C. 70 ml
D. 5 liters

# Cardiac output is a measure of :
A. Peripheral resistance * tissue fluid
B. Peripheral resistance * cardiac rate
C. Blood pressure * Cardiac rate
D. Heart rate * Stroke volume

# Cardiac output is not affected by :
A. Heart rate
B. Peripheral resistance
C. Systolic blod pressure
D. Venous return

# The largest function of the total peripheral resistance is due to:
A. Venules
B. Arterioles
C. Capillaries
D. Precapillary sphincters

# All the heart valves are open during which stage of cardiac cycle?
A. Systolic ejection
B. Isovolumetric relaxation
C. Isovolumetric contraction
D. None of the above

# Minimum blood Pressure is in:
A. Aorta
B. Arteries
C. Capillaries
D. Venules
# Starling's law of the heart
A. Does not operate in the failing heart
B. Does not operate during exercise
C. Explains the increase in cardiac output that occurs when venous return is increased
D. Explains the increase in cardiac output when the sympathetic nerves supplying the heart are stimulated

# Which of the followings is true ?
A. Starling's law of heart states that increase in force of contraction is directly related to cardiac output
B. Starling's law of heart states that the force of ventricular contraction is directly related to the end diastolic volume
C. Both A and B
D. None of the above

# Peripheral resistance is maximum in:
A. Aorta
B. Artery
C. Arteriole
D. Vein

# Stimulatuion of baroreceptor leads to :
A. Increased blood pressure, Increased heart rate
B. Decreased BP, decreased heart rate
C. Increased BP, decreased heart rate
D. Decreased BP, Increased heart rate

# Increased functional demand on the heart produces increased size of the myocardium by:
A. Hyperplasia
B. Hypertrophy
C. Fatty infiltration
D. Increased amounts of fibrous connective tissue

# Cardiac index is related to :
A. Cardiac output and body weight
B. Cardiac output and body surface area
C. Cardiac output and work of the heart
D. Stroke volume and pulse rate

# Absolute refractory period in heart :
A. Lasts till cardiac contraction
B. Longer than refractory period in skeletal muscle
C. A phase of cardiac cycle in which heart cannot be stimulated by any amount of stimulus
D. Corresponds with duration of action potential
E. All of the above

# Closure of the aortic valve occurs before the following event:
A. Isovolumetric contraction
B. Isovolumetric relaxation
C. Prediastole
D. Presystole

# Conduction velocity is least in:
A. AV node
B. SA Node
C. Purkinje fibers
D. Budele of His

# Fastest conducting tissue in human heart:
A. AV node
B. SA node
C. Bundle of His
D. Purkinje fibers

# Under resting condition, the cardiac output is ____ L/min:
A. 2.5
B. 4.25
C. 5.25
D. 9.5

# Coronary blood flow is usually predominantly controlled by :
A. Auto regulation
B. Hormones
C. Parasympathetic impulses
D. Sympathetic impulse

# Cardiac output in L/min divided by heart rate equals:
A. Cardiac efficiency
B. Cardiac index
C. Mean Stroke volume
D. Mean arterial pressure

# Cardiac cycle duration in man is:
A. 0.4 sec
B. 0.8 sec
C. 1.2 sec
D. 1.6 sec

# First heart sound occurs during the period of:
A. Isotonic relaxation
B. Isovolumetric relaxation
C. Isovolumetric contraction
D. Isotonic contraction

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Oral Cancer and Precancer of the Oral Mucosa : Histological Classification

Histological Classification of Cancer and Precancer of the Oral Mucosa
1. Carcinomas
  • Squamous cell carcinoma
  • Verrucous cell carcinoma
  • Basaloid squamous cell carcinoma
  • Adenoid squamous cell carcinoma
  • Spindle cell carcinoma
  • Adenosquamous carcinoma
  • Undifferentiated carcinoma
2. Benign lesions capable of microscopically resembling oral squamous cell carcinoma and oral verrucous carcinoma
  • Papillary hyperplasia
  • Granular cell tumor
  • Discoid lupus erythematosus
  • Median rhomboid glossitis
  • Keratoacanthoma
  • Necrotizing sialometaplasia
  • Juxtaoral organ of Chievitz
  • Chronic hyperplastic candidiasis
  • Verruciform xanthoma
  • Verruca vulgaris
  • Condyloma acuminatum
3. Precancerous lesions (Clinical classification)
  • Leukoplakia
  • Erythroplakia
  • Palatal keratosis associated with reverse smoking
4. Precancerous lesions (Histological classification)
  • Squamous epithelial dysplasia
  • Squamous cell carcinoma in situ
  • Solar keratosis
5. Benign lesions capable of resembling oral precancerous lesions
  • White lesions resembling leukoplakia
  • red lesions resembling erythroplakia
  • Focal epithelial hyperplasia
  • Reactive and regenerative atypia
6. Precancerous conditions
  • Sideropenic dysphagia
  • Lichen planus
  • Oral submucous fibrosis
  • Syphilis
  • Discoid lupus erythematosus
  • Xeroderma pigmentosum
  • Epidermolysis bullosa