MCQs on NSAIDs and other CNS Drugs - Part 2

#  All of the following statements about pain are correct except: (AIPG-01)
a) Naloxone is a non-competitive antagonist and irreversibly opposes the opioids
b) Analgesia is associated with pi and K receptors
c) Dysphoria is associated with s receptors
d) NSAIDS benefit by preventing prostaglandin synthesis

# Which of the following opioids is not given intrathecally? (AIPG-2011)
a) Sufentanil
b) Morphine
c) Remifentanil
d) Fentanyl

# Which of the following drug is used to counter act the gastric irritation produced by administration of NSAID: (AIIMS-99)
a) Pirenzipine
b) Roxatidine
c) Betaxolol
d) Misoprostol

# All are symptoms of opiate withdrawals except: (AIPG-06)
a) Lacrimation
b) Mydriasis
c) Excessive speech
d) Diarrhea

# Aspirin is contraindicated in: (AP-01)
a) Peptic ulcer
b) Angina
c) Hypertension
d) MI

# Which of the following is a muscle relaxant? (AP-06)
a) Phenylephrine
b) Succinylcholine
c) Hyoscin
d) Pentazocine

# Salicylate administration is contraindicated in pregnancy because:
a) Causes pulmonary hypertension of newborn
b) Readily erases placental barrier
c) Delay onset of labour
d) All of these

# A Hemophiliac patient has rheumatoid arthritis. Which drug might be prescribed to relieve the pain? (KCET-07)
a) Phenylbutazone
b) Acetylsalicylic acid
c) Naproxen
d) Acetaminophen

# Benzodiazepines are true in: (AIIMS-07)
a) After metabolism of other drugs in liver
b) More safe than other sedatives when take in larger amounts
c) Produce distortion in sleep more than other sedatives
d) All have metabolically active substrates

# The rate of injection of intravenous Valium is: (AIPG-05)
a) 2.5 mg / min
b) 2.5 ml / min
c) 1 mg / min
d) 1 ml / min

# Ibuprofen is contraindicated in: (KAR-04)
a) Patients having amoebic dysentery
b) Patients having fever
c) Patients having asthma
d) Patients having bronchitis

# The Ethyl alcohol (Ethanol) is more effective when mixed with water and used as: (KAR-02)
a) 10 to 20 percent
b) 60 to 70 percent
c) 40 to 50 percent
d) 20 to 30 percent

# Which one of the following is NOT an ergot alkaloids? (COMEDK-08)
a) Lysergic acid diethylamide (LSD)
b) Bromocriptine
c) Ketanserin
d) Methysergide

# An antiepileptic drug used in petitmal epilepsy is: (KAR-2K)
a) Diazepam
b) Phenobarbitonse
c) Ethosuximide
d) Dilantoin sodium

# Benzodiazepine antagonist is: (AIIMS-2008)
a) Naltrexone
b) Naloxone
c) Furazolidone
d) Flumazenil

# Which of the following is a short acting barbiturate?
a) Secobarbital
b) Mephobarbital 
c) Diazepam
d) Phenobarbital

# One of the obvious consequences of alcohol (ethanol), ingestion in many individuals is facial flushing and increased heart rate triggered off by alcohol getting metabolized to: (KAR-98)
a) Propanaldehyde
b) Butanaldehyde
c) Acetaldehyde
d) Formaldehyde

# NSAID which undergoes enterohepatic circulation: (AIPG-2010)
a) Ibuprofen
b) Piroxicam
c) Aspirin
d) Phenylbutazone

# Paracetamol is contraindicated in
a) Chronic hepatitis
b) Bleeding disorders
c) Fever
d) Nephritis

# Which of the following is a non-steroidal anti inflammatory agent with a tendency to produce blood dyscrasias? (APPSC-99)
a) Aspirin
b) Indomethacin
c) B & A
d) Ibuprofen

# An untoward effect of that is common to all phenothiazines is
a) A marked increase in blood pressure
b) Rigidity and tremor at rest, particularly with prolonged use
c) Nausea
d) Suppression of Prolactin

# Buprenorphine acts by following mechanism: (KAR-04)
a) Mu receptor partial agonist
b) Kappa receptor antagonist
c) Mu receptor antagonist
d) Kappa receptor partial agonist

# Drugs like barbiturates precipitate symptoms of porphyria because: (COMEDK-07)
a) They inhibit heme oxygenase
b) They depress ALA synthase
c) They inhibit ALA synthase
d) They induce heme oxygenase

# The principal central action of caffeine is on the: (AIIMS-2K)
a) Spinal cord
b) Cerebral cortex
c) Corpus callosum
d) Hypothalamus

# Which one of the following muscle relaxant has the maximum duration of action? (AIPG-06)
a) Rocuronium
b) Atracurium
c) Vecuronium
d) Doxacurium

# Which among the following is a pure antagonist of opioid receptors? (COMEDK-08)
a) Butorphanol
b) Naltrexone
c) Nalbuphine
d) Pentazocine

# Folic acid deficiency occurs in treatment with: (AIIMS-06)
a) Chloramphenicol
b) Phenytoin
c) Cyclosporine
d) Aspirin

# Which among the following may be used as a sedatives-hypnotic? (COMEDK-08)
a) Zolpidem
b) Zolmitriptan
c) Zalcitabine
d) Zileuton

# Which of the following drugs is currently widely used in treating opioid-dependent individuals? (AIPG-03)
a) Pentazocine
b) Methadone
c) Alphaprodine
d) Codeine

# Best and most effective drug to control convulsions in toxicity cases is: (AIPG-97)
a) Phenobarbitone
b) Diazepam
c) Phenytoin
d) Carbamazepine

# Platelet aggregation is inhibited by all except
a) Salicylates
b) Indomethacin
c) Phenobarbitone
d) Dypyradimole

# Respiratory depression is seen with: (PGI-05)
a) Antidepressants
b) Non-barbiturates
c) Synthetic narcotics
d) Tranquilizers

# Barbiturates in pediatrics is: (AIIMS-96)
a) Can be used safely
b) Contraindicated
c) Not much use
d) Low safety

# Which of the following is true about parasympathetic nervous system? (MCET-07)
a) Ach is transmitter at both pre & post synaptic junction
b) It causes dilatation of skeletal muscles
c) Post-ganglionic fibres are longer than pre ganglionic fibres
d) Noradrenalin is the neurotransmitter at post ganglionic junction

# Aspirin is contraindicated in: (AP-2010)
a) Person suffering from chicken pox or small pox
b) Peptic ulcer
c) Hemorrhage
d) All of them

# An anxiolytic, not interacting with GABAergic system and used in generalized anxiety is: (KCET-08)
a) Diazepam
b) Buspiron
c) Alprazolam
d) Phenobarbital

# A patient with grand mal epilepsy would likely be under treatment with: (AIIMS-02)
a) Phenytoin
b) Meprobamate
c) Pentobarbital
d) Trimethadione

# DOPA and 5-Hydroxytryptophan are clinically important because? (AIIMS-2009)
a) They act as neuromodulators
b) They are metabolites of various neurogenic amines
c) They are acidic precursors of Brain amines
d) They cross Blood Brain Barriers

# Gastric irritation is minimum with one of the following non-steroidal anti inflammatory drugs:
a) Indomethacin
b) Meloxicam
c) Tenoxicam
d) Piroxicam

# Acute Barbiturate poisoning results in: (AIIMS-96)
a) Liver failure
b) Renal failure
c) Convulsions
d) Respiratory failure

# The anti-inflammatory analgesic drug the causes least gastrointestinal symptoms is:
a) Phenyl butazone
b) Aspirin
c) Indomethacin
d) Paracetamol

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