MCQs on NSAIDs and Other CNS Drugs Part 1

The correct answers are highlighted in Green. Once you have finished studying these MCQs, Test yourself by watching the video at the bottom of the page.

#  Which of the following drugs is least efficacious in the treatment of temporal lobe epilepsy? (MAN-94, AIIMS-93)
a) Phenobarbitone
b) Phenytoin sodium
c) Primidone
d) Carbamazepine

# All are true of diazepenes except: (MAN-02)
a) Benzodiazepam is used in treatment of status epilepticus
b) Benzodiazepam is used in the long term treatment of psychic disorders
c) Clonazepam is used in the treatment of petit mal epilepsy
d) None of the above

# Morphine is contraindicated in all of the following except (MAN-02)
a) Pulmonary oedema 
b) Emphysema
c) Bronchial asthma 
d) Head injury

# Aspirin produces all of the following effects except: (MAN-02)
a) Frank gastric bleeding
b) Prolonged prothrombin time
c) Platelet dysfunction
d) Constipation

# Which of the following is not a contraindication in the therapy with opioids? (MAN-2K)
a) Use in head injury patient
b) Use in impaired pulmonary function
c) Use of agonist with mixed agonist-antagonist
d) Use in severe constant pain

# Which of the following can be given safely to a patient of congestive heart failure? (MAN-2K)
a) Aspirin 
b) Paracetamol
c) Diclofenac sodium 
d) Ibuprofen

# A common side effect associated with all NSAID drugs is: (MAN-98)
a) Drowsiness 
b) Gastric irritation
c) Xerostomia 
d) Constipation

# Which of the following is an irreversible side effect resulting from long term administration of phenothiazine antipsychotics? (MAN-97)
a) Infertility 
b) Parkinsonism
c) Tardive dyskinesia 
d) B & C

# Verrill's sign is seen in: (MAN-2K, AP-2001)
a) Diazepam administration
b) Digitalis toxicity
c) Paget's disease 
d) Unconscious states

# Which of the following anti inflammatory drug is a COX- 2 inhibitor? (AIPG-01)
a) Rofecoxib
b) Ketoprofen
c) Aspirin
d) Sulidec 

# One of the benzodiazepines (BDZ) comparatively safe in pregnancy is (Category -B): (KAR-2003)
a) Zolpidem
b) Lorazepam
c) Alprazolam
d) None of them

# Morphine a powerful opioid analgesic drug should be avoided in all the following conditions except: (AIPG-01)
a) Bronchial asthma
b) Left ventricular failure
c) Pancreatitis
d) Constipation

# All the following decrease skeletal muscle tone by CNS effects except: (AIPG-99)
a) Diazepam
b) D-tubocurarine
c) Baclofen
d) Mephensin

# Which of the following anti-epileptic agents causes the reversible side-effect of gingival hyperplasia? (MAN-99)
a) Sodium valproate
b) Ethosuximide
c) Phenobarbitone
d) None of them

# NSAID's have adverse effect on: (AIPG-97)
a) Liver
b) Bone
c) Stomach
d) Kidney

# Salicylate overdose in children causes: (AIPG-93)
a) Crystalluria
b) Reye's syndrome
c) Kernicterus
d) None of them

# Carbamazepine is a type of: (AIPG-97)
a) Antiemetic
b) Anti-inflammatory
c) Antidepressant
d) Antibiotic

# Drug which causes gingival hyperplasia: (AIPG-94)
a) Cyclosporin & Nifedipine
b) None of them
c) Aspirin
d) Erythromycin

# All the following statements about opioids is correct except: (AIPG-2001)
a) Pentazocine shows withdrawal symptoms in opioid dependent patients
b) Pentazocine and buprinorphine
c) Ethomorphine is similar to pethidine chemically
d) Partial agonists are free from classic opioid adverse effects

# A patient on 300 mg of aspirin will show all the following except: (AIIMS-94)
a) Prolonged bleeding time
b) Irreversible inhibition of cyclooxygenase path way
c) Inhibition of prostaglandin PGI2
d) Inhibition of thromboxane TXA2

# Thiopentone action is terminated by: (AIPG-99)
a) Metabolism
b) Redistribution
c) Excretion
d) Recycling

# Amyl nitrate is most commonly administered: (MAN-98)
a) Sub lingually
b) Orally
c) Intravenously
d) By inhalation

# Clotting time is most likely to be prolonged by the administration of:
a) Barbiturates
b) Vitamin K
c) Acetaminophen
d) Acetyl salicylic acid

# Aspirin acts on which part of brain? (AIIMS-92)
a) Cortex
b) Medulla
c) Substantia gelatinosa
d) Limbic system

# Antagonist of morphine is: (AIPG-93)
a) Nalpuphine
b) Nalosphine
c) Methadine
d) Naloxone

# Carbamazepine is contraindicated in? (AIPG - 14)
a) Temporal lobe epilepsy
b) Juvenile myoclonus epilepsy
c) None of them
d) Generalized tonic clonic

# Phenytoin is associated with: (AIPG-97, 96)
a) Cushing's syndrome
b) Folic acid deficiency
c) Vitamin C deficiency
d) Alzheimer's disease

# Aspirin causes: (AIPG-97)
a) Hemolytic anemia
b) Aplastic Anaemia
c) Hypoprothrombinemia
d) Agranulocytosis

# Aspirin is used in treatment of Myocardial Infarction: (AIPG-02)
a) It inhibits thromboxanes
b) It helps in reducing inflammatory aggregate
c) It stimulates Prostacyclins
d) It is a vasodilator

# Amitryptyline is a: (AP-03)
a) Tricyclic antidepressant
b) Sedative
c) Antibiotic
d) Diuretic

# Drug which is used to control status epitepticus is: (AP-97, AIPG-93)
a) Glyceryl trinitrite
b) Phero barbital
c) Sodium nitroprusside
d) Diazepam

# Narcotic overdose can be antagonized by: (MAN-99)
a) Nalorphine
b) Naloxone
c) Diphenhydramine
d) Atropine

# An attack of migraine can be easily terminated by: (AIPG-99)
a) Acetylcholine
b) Ergotamine
c) Morphine
d) Ibuprofen

# Which of the following drugs causes extra pyramidal symptoms? (PGI-2K)
a) Antibiotics
b) Barbiturates
c) Salicylates
d) Phenothiazines

# Pregnant patient can be safely given: (AP-2K)
a) Paracetamol
b) Barbiturates
c) Tetracycline
d) Metronidazole

# Aspirin is avoided in children with influenza infection because of association of: (KAR-99)
a) Nausea
b) Diarrhoea
c) Acid-base imbalance
d) Reye's syndrome

# Nausea and vomiting that are associated with administration of opioid analgesic is the result of stimulation of the: (MAN-97)
a) Emetic system
b) Opioid receptors in G.I.T.
c) Limbic system
d) Chemoreceptor trigger zone (CTZ)

# Prolonged use of aspirin causes: (AIPG-98)
a) Hypophosphatasia
b) Hypercalcemia
c) Hyperprothrombinemia
d) Hypoprothrombinemia

# The intramuscular administration of 0.6 mg of atropine sulphate to a 50 kg adult may produce all of the following: effects except: (AIIMS-93)
a) Mydriasis
b) Bradycardia
c) Decreased sweating
d) Decreased salivation

# Prolonged use of aspirin leads to: (AIPG-98)
a) Carcinoma
b) Bleeding defects
c) Peptic ulcer
d) B & C

# Phenothiazines are used to: (AIPG-2003)
a) Suppress coughing
b) Produce muscle relaxation
c) Alter psychotic behaviour
d) Produce analgesia

#  A 50 year old female with end stage renal disease (ESRD), develops pulmonary tuberculosis. Which one of the following drugs should be used in a reduced dose? (KCET-2011)
a) Ethambutol
b) Pyrazamide
c) Isoniazide
d) Rifampicin

# Drug that does not cause sedation: (AIPG-2011)
a) Zopiclone
b) Nitrazepam
c) Buspirone
d) Diazepam

# An attack of bronchial asthma is most likely to be triggered by: (KAR-99)
a) Aspirin
b) Mefenamic acid
c) None of them
d) Diclofenac potassium

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