Type II Diabetes Causes

# Obesity, genetic profile, and aging all contribute to the development of Type II diabetes. Of the following, which is the most important additive factor for these three conditions in the development of Type II diabetes?

A. elevated hepatic ketogenesis
B. elevated pancreatic glucagon secretion
C. impaired renal clearance of glucose
D. muscle resistance to insulin

Answer: D - Muscle resistance to insulin is the most important additive factor for these three conditions in the development of Type II diabetes. The progressive loss of skeletal muscle sensitivity to insulin leads to increased rates of visceral cell lipolysis and pancreatic beta-cell compensation.