What is best for factor VIII replacement in Hemophilia A:

 # What is best for factor VIII replacement in Hemophilia A?

A. Fresh frozen plasma

B. Cryoprecipitate

C. Whole blood

D. Platelets

The correct answer is B. Cryoprecipitate.

Cryoprecipitate is a source of fibrinogen， factor VIII，and von Willebrand factor (VWF). It is ideal for supplying fibrinogen to the volume-sensitive patient. When factor VIII concentrates are not

available， cryoprecipitate may be used because each unit contains approximately 80 units of factor VIII. Cryoprecipitate may also supply VWF to patients with dysfunctional (type II) or absent (type III) von Willebrand's disease. 

Reference: Harrison's Principles of Internal Medicine, 19th Edition, Page no: 138e-3

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