Which drug should be avoided by patient with severe renal impairment?

 # Which drug should be avoided by patient with severe renal impairment?

A. Aminoglycosides

B. Rifampicin

C. Glibenclamide

D. Clofibrate

The correct answer is A. Aminoglycosides.

Certain drugs worsen the existing clinical condition in renal failure, e.g.

• Tetracyclines have an anti-anabolic effect and accentuate uraemia.

• NSAIDs cause more fluid retention.

• Potentially nephrotoxic drugs, e.g. aminoglycosides, tetracyclines (except doxycycline), sulfonamides (crystalluria), vancomycin, nitrofurantoin, cyclosporine, amphotericin B should be avoided.

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