Which of the following drugs is likely to damage the eighth cranial nerve when administered for a long period of time ?

 # Which of the following drugs is likely to damage the eighth cranial nerve when administered for a long period of time ?

 A. Ethambutol

 B. Isoniazide

 C. Rifampicin

 D. Streptomycin

The correct answer is D. Streptomycin.

Nephrotoxicity, ototoxicity, and contact sensitization (due to this, topical application is not indicated) are common side effects of Streptomycin. 8th nerve is usually affected. Vestibular involvement is more common and cochlear involvement is less common.