# Which of the following is the strongest activator of platelet?

 # Which of the following is the strongest activator of platelet? 

a. Thrombin 

b. Serotonin 

c. Thromboxane A2 

d. Epinephrine

The correct answer is: A. Thrombin.

Strong activator: Thrombin Collagen ADP, Shear

Weak: Epinephrine Thromboxane A2/Prostoglandin H2 Serotonin Platelet activating factor Vasopressin Thrombospondin-1 Thrombolytic agent

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Most common cause of thrombocytopenia in children is:

# Most common cause of thrombocytopenia in children is:

a. Aplastic anemia 

b. ITP

c. TTP 

d. Drug induced

The correct answer is B. ITP.

ITP is the most common cause of acquired severe thrombocytopenia and 50% of ITP cases are children, i.e. < 10 years of age. 

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One unit of random donor platelet ideally increases the platelet count in an adult by:

 # One unit of random donor platelet ideally increases the platelet count in an adult by: 

a. 5000 

b. 10000 

c. 15000 

d. 20000

The correct answer is: a. 5000.

The increment in platelet count depends on many factors but if all other factors are absent then 1 unit of whole blood derived random platelet increases the platelet count by 5,000/mm3 per square metre. So in a person of BSA 2 m2. It should raise by 10000/mm3 and of 1.5 m2 by 7500/mm3 respectively. 

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Which of the following can be given safely in pregnancy?

 # Which of the following can be given safely in pregnancy? 

a. Imatinib 

b. Heparin 

c. Warfarin 

d. Thalidomide

The correct answer is B. Heparin.

Human Teratogenic Drugs - Drugs causing human birth defect

Thalidomide – Phocomelia, multiple defects

All anticancer drugs – Multiple defects, fetal death

Androgens – Virilization, limb, esophageal, cardiac defects

Progestins – Virilization of female fetus

Tetracycline – Discolored and deformed teeth, retarded bone growth

Warfarin – Nose, eye and hand defects, growth retardation

Phenytion – Hypoplastic phalanges, cleft lip/palate microcephaly

Phenobarbitone – Various malformations

Chlorpromazine – Neural tube defects

Valproate sodium – Spina bifida and other normal tube defects

Lithium – Fetal goitre, cardiac and other abnormalities

Isotretinoin – Craniofacial, heart and CVS defects

Imatinib – Multiple defects exomphalos, kidney abnormalities

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