Thesis Topic Ideas for MDS Orthodontics

 Thesis and research is a part of MDS curriculum. Here are some good research topics to consider if you are an MDS Orthodontics Resident.

1. Assessment of the relationship between maxillary and mandibular incisors in Class I, Class II, and Class III malocclusions
2. Evaluation of the effectiveness of different treatment modalities for correcting Class II malocclusion in growing patients
3. Comparison of the effectiveness of fixed and removable functional appliances in correcting Class II malocclusion

Hemifacial microsomia is a feature of:

 # Hemifacial microsomia is a feature of:

A. Goldenhar syndrome

B. Crouzon syndrome

C. Treacher Collins syndrome

D. Mandibulofacial dysostosis

The correct answer is A. Goldenhar syndrome.

Hemifacial microsomia is a feature of Goldenhar syndrome. Synonyms for hemifacial microsomia include hemifacial hypoplasia, craniofacial microsomia, lateral facial dysplasia, Goldenhar syndrome, and oculoauriculovertebral dysplasia (OAV) spectrum. 

B is incorrect; Hemifacial microsomia is not a feature of Crouzon syndrome. Patients with Crouzon syndrome characteristically have brachycephaly (short skull front to back), hypertelorism (increased distance between eyes), and orbital proptosis (protruding eyes). 

C is incorrect; Hemifacial microsomia is not a feature of Treacher Collins syndrome. The most common clinical findings in Treacher Collins syndrome are relative underdevelopment or absence of the zygomatic bones, resulting in a small narrow face; a downward inclination of the palpebral fissures; underdevelopment of the mandible, resulting in a down-turned, wide mouth; malformation of the external ears; absence of the external auditory canal; and occasional facial clefts. 

D is incorrect, Mandibulofacial dysostosis is a synonym of Treacher Collins syndrome.

The gene aberrant in dentinogenesis imperfecta is:

 # The gene aberrant in dentinogenesis imperfecta is:

A. Chromosome 4

B. Chromosome 13

C. Chromosome 21

D. Chromosome 24

The correct answer is A. Chromosome 4.

Aberration in chromosome 4 (4q21.3) is associated with Dentinogenesis imperfecta. It encodes dentin specific sialophosphoprotein (DSPP) gene. Deficiency of sialoprotein is also suggested as a causative factor for DI. They are generally tulip shaped. 

Chromosome number              Disease 

1                                               Vanderwoude syndrome

4                                               Dentinogenesis Imperfecta 

4                                               Cherubism

15                                             Marfan's syndrome

19                                             Osteogenesis imperfecta

Deficiency of which vitamin causes glossitis, dementia, rough keratotic areas on skin and gastrointestinal symptoms?

 # Deficiency of which vitamin causes glossitis, dementia, rough keratotic areas on skin and gastrointestinal symptoms?

A. Riboflavin

B. Pyridoxine

C. Niacin

D. Pantothenic acid

The correct answer is C. Niacin.

Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. Areas of the skin exposed to either sunlight or friction are typically affected first. Over time affected skin may become darker, stiffen, peel, or bleed.

There are two main types of pellagra, primary and secondary. Primary pellagra is due to a diet that does not contain enough niacin and tryptophan. Secondary pellagra is due to a poor ability to use the niacin within the diet. This can occur as a result of alcoholism, long-term diarrhea, carcinoid syndrome, Hartnup disease, and a number of medications such as isoniazid. Diagnosis is typically based on symptoms and may be assisted by urine testing.