The Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) and the Index of Orthodontic Treatment Need (IOTN) are both used to assess treatment need. Which component of the IOTN is most directly correlated with the patient-reported concerns measured by the PIDAQ?
Based on current, high-level evidence, which occlusal feature has demonstrated the strongest, albeit weak, statistical association with an increased prevalence of pain-related Temporomandibular Disorders (TMD)?
High-level evidence from systematic reviews, such as the 2025 review by Alghamdi et al. in Frontiers in Neurology (analyzing 17 studies on children/adolescents), identifies posterior unilateral crossbite as having the strongest association with pain-related TMD signs/symptoms, including TMJ/muscle pain and tenderness. Pooled data show odds ratios (ORs) of 2.25–5.74 (95% CIs: 1.15–4.43 to 1.18–27.85; p<0.05 across studies like Pereira et al. 2009 and Perrotta et al. 2018), indicating a 2–6-fold increased risk, though with low GRADE certainty due to cross-sectional designs and heterogeneity. This exceeds associations for other features: anterior open bite (OR ~1.5–2.0 in select studies, e.g., Sonnesen 1998); Class II Division 2 (OR 2.61 for general Class II, but weaker/subgroup-specific for Div 2, per Šimunović et al. 2024); and overjet ≥6 mm (OR ~1.8–2.5, less consistent in mixed/permanent dentition per Manfredini et al. 2010). A 2025 meta-analysis by Chen et al. in BMC Oral Health reports 59% TMD prevalence in unilateral crossbite cases (95% CI: 46%–72%), vs. 40%–44% for others. Overall, while all links are weak (ORs <6, multifactorial etiology), crossbite shows the most consistent statistical signal.
The primary mechanism by which severe mandibular incisor crowding is hypothesized to independently increase the risk of localized periodontal breakdown, beyond confounding factors like poor hygiene, is:
Severe mandibular incisor crowding causes teeth to displace or rotate within the alveolar housing, violating bone constraints and leading to cortical plate resorption. This results in fenestrations (narrow bone defects exposing root surfaces) and dehiscences (wider marginal defects causing gingival recession and reduced bone support), increasing localized periodontal breakdown risk independently of plaque accumulation or hygiene. Studies, including a 2024 review in the British Dental Journal, highlight that crowded, labially displaced incisors often lack adequate labial gingival coverage, while lingual positioning creates excess tissue and undermined support, predisposing to attachment loss. Proclined incisors in crowded arches show up to a 50% chance of 2 mm bone loss per 8° of proclination, per CBCT analyses. This mechanism differs from hygiene-related plaque retention (option C) or secondary effects like mobility (option B), and while horizontal forces (option A) may contribute, displacement-induced defects are the primary hypothesized pathway in orthodontic literature.
Primary determinant for a clinically significant increase in the risk of maxillary incisor trauma in the mixed dentition
Systematic reviews, including Nguyen et al. (1999) in the European Journal of Orthodontics, show that an overjet ≥3 mm approximately doubles the risk of maxillary incisor trauma in children, including mixed dentition, based on a meta-analysis of 11 studies (pooled OR ≈2.0). This threshold is consistently cited as the point where risk significantly increases, with ORs ranging from 1.94 to 5.19 in mixed dentition per Arraj et al. (2019) in Dental Traumatology (41 studies). Later reviews, like Pandis et al. (2022) in the British Dental Journal, reinforce >3 mm as a key early indicator for trauma risk in mixed/permanent dentitions (7–14 years).
Higher thresholds like ≥6 mm show stronger associations (OR 3.85) but only in permanent dentition, not consistently in mixed. ≥4.5 mm and ≥1.5 mm lack support in reviews for this stage. Thus, ≥3 mm is the most consistently backed primary determinant.
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Dental MCQs - Multiple Choice Questions in Dentistry
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