MCQs on Pharmacology - Chemotherapy / Antibiotics

The correct answers are highlighted in green.

# The most common side effect of the oral administration of ampicillin is: (MAN-94, AIIMS-93)
a) Anaphylactic shock
b) Diarrhoea
c) Oral candidiasis
d) Renal failure

# Which of the following drugs is likely to damage the eighth cranial nerve when administered for a long period of time? (MAN-94)

a) Ethambutol

b) Isoniazid

c) Rifampicin

d) Streptomycin 

# Which of the following is primarily a bactericidal drug? (MAN-95)

a) Chloramphenicol

b) Gentamicin

c) Sulphadiazine

d) Tetracycline

# Penicillin is effective against: (MAN-95)

a) Neisseria meningitis

b) Neisseria gonorrhoeae

c) Treponema pallidum

d) All of the above

# The therapeutic advantage that penicillin V has over penicillin G is: (MAN-98)

a) More reliable oral absorption

b) Greater resistance to pencillinase

c) Slower renal excretion

d) Broader antibacterial spectrum

# Concurrent administration of tetracyclines is most likely to impair the action of: (MAN-98)

a) Lincomycin

b) Chloramphenicol

c) Erythromycin

d) Penicillin

# Chloramphenicol can cause: (MAN-99)

a) Staining of teeth

b) Aplastic anaemia

c) Bone marrow suppression

d) B & C

# Which drug causes photosensitivity? (MAN-99)

a) Tetracycline

b) Aminoglycoside

c) Penicillin

d) Cephalosporin

# The antibiotic of choice in patients sensitive to penicillin is : (MAN-98, KAR-03)

a) Erythromycin

b) Streptomycin

c) Tetracycline

d) Chloramphenicol

# Which of the following penicillins can be given by IV route? (MAN-99)

a) Benzathine

b) Procaine

c) Crystalline

d) Benzathamine

# Tetracycline is contraindicated in: (MAN-99)

a) Children

b) Pregnancy

c) Renal failure

d) All the above

# Fluconazole is used for the treatment of: (MAN-2001)

a) Pemphigus

b) Herpes simplex

c) Candidiasis

d) Syphilis

# Mechanism of action of quinolones is: (MAN, AIPG-2K)

a) Inhibits DNA gyrase

b) Inhibits bacterial protein synthesis

c) Inhibits bacterial cell wall synthesis

d) Inhibits intake of folic acid

# A child with permanently stained teeth reports. He was most probably administered: (MAN-99)

a) Diphenyl hydantoin

b) Diphenhydramine

c) Digoxin

d) Doxycycline 

# The bacterial resistance to tetracycline is due to: (MAN-2K, AIPG-93)

a) Alteration of drug binding sites

b) Alteration of dihydrofolate reductase

c) Inactivation of drug by enzymes

d) uptake of drug by bacteria

# In the treatment of intestinal and extraintestinal amoebiasis which of the following drug is useful: (AIPG-99)

a) Metronidazole

b) Cefaclor

c) Chloroquine

d) Diloxane

# A patient taking which of the following drug should not eat cheese, etc: (AIIMS-98, A P-04)

a) Doxycycline

b) Amoxycillin

c) Triamterene

d) Tetracycline

# Antifungal drug not used in the treatment of intestinal candidiasis: (MAN-2K)

a) Clotrimazole

b) Amphotericin

c) Nystatin

d) Ketoconazole

# Ototoxicity and nephrotoxicity is caused by: (AIPG-97)

a) Antibiotic

b) Antiemetic

c) Antifungal

d) Antiviral

# Which one of the following antibiotics chelates with calcium? (AIIMS-95, 01, AIPG-04)

a) Tetracycline

b) Cephalosporins

c) Erythromycin

d) Penicillin 

#  Prolonged administration of streptomycin results in damage to the: (AIIMS-02)

a) Facial nerve

b) Auditory nerve

c) Optic nerve

d) Trigeminal nerve

# Stepwise mutation for drug resistance is seen with: (KAR-98)

a) Streptomycin

b) Kanamycin

c) Penicillin

d) Garamycin

# Desfuroxamide is a drug used for: (AIPG-95)

a) Pernicious anaemia

b) Thalassemia

c) Kala-azar

d) Pain control

# The oropharyngeal and oesophageal candidiasis following long-term therapy with a broad spectrum antibiotic can be best treated with: (KAR-97)

a) Sulfonates

b) Griseofulvin

c) Fluconazole

d) Amphotericin

# Cephalosporins have all of the following interactions except: (AIIMS-95)

a) Have a broad spectrum but are inactive against anaerobes

b) Are used in upper respiratory tract infections

c) Show cross sensitivity with penicillins

d) Are penicillinase resistant

# Which antibiotic is effective against pseudomonas and indole +ve proteus? (AIIMS-92)

a) Oxacillin

b) Methicillin

c) Lincomycin

d) Carbenicillin

# Oral infection by penicillinase producing organisms should be treated with: (AIIMS-94)

a) Ampicillin

b) Erythromycin

c) Dicloxacillin

d) All of them

#  A distinct advantage that tetracyclines have over penicillins is that tetracyclines: (AIPG-03)

a) Have no side effects

b) Do not cause superinfections

c) Are safer to use during pregnancy

d) Have a wider range of antibacterial activity

# Peripheral neuritis is a complication of:

a) Rifampicin

b) Ethambutol

c) Pirazinamide

d) Isoniazid

# Which of the following antibiotics is most frequently associated with pseudomembranous colitis? (AIIMS-95, AP-08)

a) Penicillin

b) Clindamycin

c) Ampicillin

d) Cephalosporin

# Antibiotic that interferes with DNA function is:  (AIIMS-2K)

a) Tetracycline

b) Nystatin

c) Sulphonamides

d) Metronidazole

# Which one of the following is penicillinase-resistant penicillin: (AIIMS-2K, AIPG-96)

a) Amoxycillin

b) Penicillin G

c) Ampicillin

d) Cloxacillin

# One of the below-mentioned penicillin is NOT given orally: (KAR-97)

a) Phenoxymethyl penicillin

b) Amoxicillin

c) Carbenicillin

d) Cloxacillin

# The drug of choice for treatment of typhoid is

a) Tetracycline

b) Cefotaxim

c) Metronidazole

d) Ciprofloxacin

# When broad-spectrum antibiotics are administered with coumarin anticoagulants, the anticoagulant action may be: (AIIMS-2K)

a) Reduced because of increased protein-binding

b) Reduced because of enhanced hepatic drug metabolism

c) Increased because of decreased renal excretion of the anticoagulant

d)  Increased because of reduction of vitamin K sources

# Granesetron, has antiemetic properties because of: (AIPG-99)

a) Gaba-inhibitory actions

b) Dopaminergic receptor - blocking actions

c) Gabamimetic actions

d) Serotonin receptor-blocking action.

# A patient suffering from syphilis is given pencillin. He may develop: (MAN-2K)

a) Grey syndrome

b) Jarisch - Herxheimer reaction

c) Cholestatic Jaundice

d) Fanconi Syndrome

 # A patient has seasonal allergic rhinitis and is on terfenadine. He develops cardiac arrhythmias  after a course of antibiotics. Which of the following antibiotic could have been given?

a) Cotrimoxazole

b) Erythromycin

c) Tetracycline

d) Ampicillin

# Which of the following penicillins is given by oral route? (AIPG-95)

a) Benzathine penicillin

b) Penicillin V / Phenoxymethyl penicillin

c) Benzyl penicillin

d) Procaine pencillin

# The drug for choice for treatment of infection involving non-penicillinase producing staphylococcus is: (AIIMS-99)

a) Erythromycin

b) Penicillin G

c) Ampicillin

d) Methicillin sodium

# Drug chemically related to penicillins is: (AIPG-94)

a) Lincomycin

b) Sulphonamide

c) Tetracycline

d) Cephalosporin

# The drug which gives orange colour to the urine is: (AIIMS-98)

a) Streptomycin

b) INH

c) Rifampicin

d) Ethambutol

# Clavulanic add added to ampicillin causes: (AIIMS-98)

a) Increase effectivity against gram-positive organisms

b) Inhibition of beta lactamases

c) Increase effectivity against gram-negative organisms

d) Increases the effectiveness against delta lactamase producing organism

# Which of the following is caused by Amphotericin B? (AIIMS-2004)

a) Hyperkalemia

b) Hypermagnesemia

c) Hyponatremia

d) Hypokalemia

# The mechanism of action of chloramphenicol is the inhibition of synthesis of: (KAR-97)

a) Cell wall

b) Cell membrane

c) Protein

d) DNA

# Combination chemotherapy is used in tuberculosis in order to reduce: (KAR-97)

a) Dosage of drugs

b) Side effects of drugs

c) Cost of therapy

d) Development of drug resistance