Agranulocytosis

# Agranulocytosis refers to:

A. Increased production of agranulocytes

B. Decreased production of granulocytes

C. Decreased production of lymphocytes

D. None of the above

The correct answer is B. Decreased production of granulocytes.

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Philadelphia chromosome

# True about Philadelphia chromosome is:

A. Seen in CML

B. Due to reciprocal translocation from chromosome 9 to 22 and vice versa

C. It is a prognostic feature

D. All of the above

The correct answer is D. All of the above.

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Chronic Lymphocytic thyroiditis refers to:

# Chronic Lymphocytic thyroiditis refers to:

a) Tuberculous thyroiditis 

b) Hashimoto's thyroiditis

c) Dequervain's thyroiditis 

d) Riedel's thyroiditis

The correct answer is B. Hashimoto's Thyroiditis.

Hashmimoto's thyroiditis:

• Most common type of thyroiditis

• Autoimmune; raised titres of thyroid antibodies.

• Mild hyperthyroidism may be present initially but hypothyroidism is inevitable.

• Characteristic 'bosselated' feel with soft, rubbery or firm in consistency; Hurthle cells present.

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Auer bodies are a characteristic of:

# Auer bodies are a characteristic of:
A. Plasma cells
B. Monocytes
C. Myeloblasts
D. Reticulocytes

The correct answer is C. Myeloblasts.

Myeloblasts may have intracytoplasmic  rods (stain red) called Auer rods. Auer rods are abnormal lysosomes (primary granules) that are pathognomic of myeloblasts and not found in ALL. Auer rods also stain positive with myeloperoxidase. The diagnosis of AML is established by the presence of >20% myeloblasts in blood and/or bone marrow. A positive myeloperoxidase reaction in >3% of the blasts may be the only feature distinguishing AML from acute lymphoblastic leukemia (ALL).

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