MCQs in Pharmacology : Antibiotics, antivirals and antifungals

# The most common side effect of the oral administration of ampicillin is : A. Anaphylactic shock
B. Diarrhoea
C. Oral Candidiasis
D. Renal failure

# Which of the following drugs is likely to damage the eighth cranial nerve when administered for a long period of time ?
A. Ethambutol
B. Isoniazide
C. Rifampicin
D. Streptomycin

# Which of the following is primarily a bactericidal drug ?
A. Chloramphenicol
B. Gentamicin
C. Sulphadiazine
D. Tetracycline

# Penicillin is effective against :
A. Neisseria meningitidis
B. Neisseria gonorrhoeae
C. Treponema pallidum
D. All of the above

# The therapeutic advantage that penicillin V has over penicillin G is :
A. more reliable oral absorption
B. greater resistance to penicillinase
C. slower renal excretion
D. broader antibacterial spectrum

# Concurrent administration of of tetracyclines is most likely to impair the action of :
A. Lincomycin
B. Chloramphenicol
C. Erythromycin
D. Penicillin

# Chloramphenicol can cause :
A. Staining of teeth
B. Aplastic anemia
C. Bone marrow suppression
D. Both B and C

# Which drug causes photosensitivity ?
A. Tetracycline
B. Aminoglycosides
C. Penicillin
D. Cephalosporin

# The antibiotic of choice in patients sensitive to penicillin is:
A. Erythromycin
B. Streptomycin
C. Tetracycline
D. Chloramphenicol

# Which of the following penicillins can be given by IV route ?
A. Benzathine
B. Procaine
C. Crystalline
D. Benzathine

# Tetracycline is contraindicated in :
A. Children
B. Pregnancy
C. Renal failure
D. All of the above

# Fluconazole is used for the treatment of :
A. Pemphigus
B. Herpes simplex
C. Candidiasis
D. Syphilis

# Mechanism of action of quinolones is :
A. inhibits DNA gyrase
B. inhibits bacterial protein synthesis
C. inhibits bacterial cell wall synthesis
D. inhibits intake of folic acid

# A child with permanently stained teeth reports. He was most probably administered :
A. Disphenyl hydantoin
B. Diphenhydramine
C. Digoxin
D. Doxycycline

# The bacterial resistance to tetracycline is due to :
A. alteration of drug binding stes
B. alteration of dehydrofolate reductase
C. inactivation of drug by enzymes
D. decreased uptake of drug by bacteria

# A patient suffering from syphilis is given penicillin. He may develop :
A. Cholestatic jaundice
B. Grey Syndrome
C. Fanconi syndrome
D. Jarisch Herxheimer syndrome

# The drug of choice for typhoid is :
A. Tetracycline
B. Metronidazole
C. Ciprofloxacin
D. Cefotaxim

# Peripheral neuritis is a complication of :
A. Isoniazide
B. Ethambutol
C. Rifampicin
D. Pirazinamide

# Antifungal drug not used in the treatment of intestinal Candidiasis is :
A. Ketoconazole
B. Amphotericin
C. Nystatin
D. Clotrimazole

# When broad spectrum antibiotics are administered with coumarin anticoagulants, the anticoagulant action may be :
A. reduced because of enhanced drug metabolism
B. reduced because of increased protein binding
C. Increased beacuse of reduction of vitamin K sources
D. Increased because of decreased renal excretion of the anticoagulant

# A patient has seasonal allergic rhinitis and is on terfenadine. He develops cardiac arrhythmia after a course of antibiotics. Which of the following antibiotic could have been given ?
A. Ampicillin
B. Tetracycline
C. Erythromycin
D. Cotrimoxazole

# Granesetron has antiemetic properties because of :
A. Dopaminergic receptor - blocking actions
B. GABA mimetic actions
C. GABA inhibitory actions
D. Serotonin receptor blocking action

# Desfuroxamide is a drug used for :
A. Kala-azar
B. Pernicious anemia
C. Pain control
D. Thalassemia

# The mechanism of action of chloramphenicol is inhibition of synthesis of :
A. Cell wall
B. Cell membrane
C. Protein

# Which of the following is penicillinase resistant penicillin ?
A. Amoxicillin
B. Coxacillin
C. Ampicillin
D. Penicillin G

# A patient taking which of the following drug should not eat cheese ?
A. Tetracycline
B. Amoxycillin
C. Doxycycline
D. Triamterene

# The drug which gives orange red color to the urine is :
A. Rifampicin
B. Ethambutol
C. Isoniazide
D. Streptomycin

# Prolonged administration of streptomycin may result in the damage of :
A. Optic nerve
B. Facial nerve
C. Auditory nerve
D. Trigeminal nerve

# In the treatment of intestinal and extraintestinal amoebiasis , which of the following drug is useful ?
A. Diloxane
B. Metronidazole
C. Chloroquine
D. Cefaclor

# Which of the following antibiotics is most frequently associated with pseudomembranous colitis ?
A. Ampicillin
B. Penicillin
C. Clindamycin
D. Cephalosporin

# Cephalosporins have all of the following interactions except :
A. show cross sensitivity with penicillins
B. are penicillinase resistant
C. have a broad spectrum but are inactive against anaerobes
D. are used in upper respiratory tract infections

# A distinct advantage that tetracyclines have over penicillins is that tetracyclines:
A. have no side effects
B. do not cause superinfections
C. are safer to use during pregnancy
D. have wider range of bacterial activity

# Clavulanic acid added to ampicillin causes :
A. increased effectiveness against gram negative organisms
B. inhibition of B lactamases
C. Increases the effectiveness against delta lactamase producing organisms
D. Increase effectiveness against gram positive organisms

# Which antibiotic is effective against Pseudomonas and indole positive proteus ?
A. Methicillin
B. Carbenicillin
C. Lincomycin
D. Oxacillin

# Which one of the following antibiotics chelates with calcium ?
A. Penicillin
B. Tetracycline
C. Cephalosporins
D. Erythromycin

# Antibiotic that interferes with DNA function is :
A. Metronidazole
B. Nystatin
C. Tetracycline
D. Sulphonamides

# Combination chemotherapy is used in tuberculosis in order to reduce :
A. side effects of drugs
B. Cost of therapy
C. Dosage of drugs
D. Development of drug resistance

# The oropharyngeal and oesophageal candidiasis following long term therapy with a broad spectrum antibiotic can be best treated with :
A. Griseofulvin
B. Amphotericin
C. Fluconazole
D. Sulfonates

# One of the below mentioned penicillin is NOT given orally :
A. Amoxicillin
B. Carbenicillin
C. Cloxacillin
D. Phenoxy methyl penicillin

# The treatment of choice for treatment of infection involving non-penicillinase producing Staphylococcus is :
A. Ampicillin
B. Erythromycin
C. Penicillin G
D. Methicillin sodium

# Ototoxicity and nephrotoxicity is caused by :
A. Antiemetic
B. Antifungal
C. Antiviral
D. Antibiotic

# Drug chemically related to penicillins is :
A. Tetracycline
B. Sulphonamide
C. Cephalosporin
D. Lincomycin

# Which of the following penicillins is given by oral route ?
A. Benzyl penicillin
B. Benzathine penicillin
C. Procaine penicillin
D. Penicillin V / Phenoxymethyl penicillin

# Stepwise mutation for drug resistance is seen with :
A. Penicillin
B. Streptomycin
C. Garamycin
D. Kanamycin

# Oral infection by penicillinase producing organisms should be treated with:
A. Ampicillin
B. Dicloxacillin
C. Erythromycin
D. Any of these

# Which of the following is caused by Amphotericin B :
A. Hypokalemia
B. Hyperkalemia
C. Hypermagnesemia
D. Hyponatremia

# Among the drugs given below, which is least likely to be implicated in drug induced hepatitis ?
A. Isoniazide
B. Streptomycin
C. Rifampicin
D. Pyrazinamide

# Optic neuritis is a side effect of :
A. Rifampicin
B. Isoniazide
C. Pyrazinamide
D. Ethambutol

# Which of the following drug control lepramin reaction ?
A. Dapsone
B. Streptomycin
C. Clofazimine
D. Ethambutol

# Oral contraceptive failure occurs in a patient on Rifampicin because of :
A. Rifampicin induce the metabolism of contraceptive
B. Rifampicin stimulates the gonadotropin release from pituitary
C. Rifampicin decrease the secretion of progestin
D. Rifampicin antagonize the action of oral contraceptive

# The most serious side effect of drug chloramphenicol is :
A. Candidiasis
B. Photosensitivity
C. Bone marrow depression
D. Angioneurotic oedema

# Tetracycline is more preferred in periodontics because :
A. It is a broad spectrum antibiotic
B. It has anti collagenolytic effect
C. Both A and B
D. None of the above

# Drug which is most unsafe during pregnancy is :
A. Ethambutol
B. Streptomycin
C. Kanamycin
D. Both B and C

# Tetracycline in children causes :
A. Calcification
B. Missing teeth
C. Discolored teeth
D. Peg teeth

# The aminoglycoside with least toxic effect is :
A. Ethambutol
B. Isoniazide
C. Streptomycin
D. Kanamycin

# First line of antitubercular drug is :
A. Streptomycin
B. Isoniazide
C. Ethambutol
D. Cephalosporins

# Cell wall synthesis is inhibited by all except:
A. Lincomycin
B. Penicillin
C. Cephalexin
D. Ampicillin

# Metronidazole is a type of :
A. Broad spectrum antibiotic
B. Quinolone
C. Imidazole derivative
D. Antidepressant

# Bacitracin is a :
A. Oral antibiotic
B. Topical antibiotic
C. Parenteral antibiotic
D. All

# Antibiotic that achieves high concentration in hard tissue because of its molecular size is:
A. Ceftum
B. Ciprofloxacin
C. Clindamycin
D. Erythromycin

# Tetracycline chelates with:
A. Ca salts
B. Mg salts
C. All salts
D. All of the above

# Phototoxicity is the side effect of :
A. Penicillin
B. Demeclocycline
C. Erythromycin
D. Streptomycin

# Drugs producing ototoxicity and nephrotoxicity are :
A. Tetracyclines
B. Aminoglycosides
C. Quinolones
D. Macrolides

# Which among the following given drugs does not act by protease inhibition ?
A. Ritonavir
B. Saquinavir
C. Nelfinavir
D. Zanamivir

# Which of the following antibiotics is effective in treating oral candidiasis ?
A. Nystatin
B. Bacitracin
C. Penicillin
D. Tetracycline

# Drug of choice in amoebic liver abscess besides metronidazole is :
A. Ciprofloxacin
B. Chloroquin
C. Menendazole
D. Bephenium Naphthoate

# Traces of which of the following antibiotics can be found in gingival fluid after administration ?
A. Tetracycline
B. Lincomycin
C. Clindamycin
D. Penicillin G

# The following are the indications for metronidazole except :
A. Ulcerative gingivitis
B. Amoebiasis
C. Trichomonas infection
D. Streptococcal sore throat

# The following adverse effect of Penicillin is dose related:
A. Skin rash
B. Interstitial nephritis
C. Drug fever
D. Encephalopathy

# One of the following drugs is B lactamase inhibitor :
A. Ampicillin
B. Sulbactam
C. Cloxacillin
D. Streptomycin

# Mechanism of action of chlortetracycline is :
A. interfere with metabolism
B. Inhibition of protein synthesis
C. Inhibition of cell wall formation
D. Interfere with DNA function

# The oral microbial flora of a patient on prolonged broad spectrum antibiotic therapy is predominantly :
A. Anaerobic
B. Gram positive organisms
C. Gram negative organisms
D. Yeast and fungi

# Agent used in oral thrush :
A. Miconazole
B. Clobetasol
C. Clotrimazole
D. Amoxycillin

# All of the following cephalosporins are active against Pseudomonas except :
A. Ceftazidine
B. Cefotaxime
C. Cefoperazone
D. Cefaclor

# All of the following statement about antimalarial drugs are correct except :
A. Primaquine is liable to cause hemolysis in patients with G6PD deficiency
B. Halofantrine prolongs QT interval and causes dysarrhythmia
C. Mefloquine may safely be given to air pilots
D. Primaquine eliminates P. vivax and P. ovale

# More potent and non toxic drug against herpes virus is :
A. Zidovudine
B. Acyclovir
C. Nystatin
D. Amantidine

# Which antitubercular drug will cause transient memory loss ?
A. Ethionamide
C. Ethambutol
D. Pyrazinamide

# Which among the following is the drug of choice for clostridium difficile - induced colitis ?
A. Gentamicin
B. Ciprofloxacin
C. Metronidazole
D. Linezolid

# Which of the following is the main difference between penicillin-V and penicillin-G ?
A. Penicillin V is more stable in gastric acid
B. Penicilin G is more absorbed from the GIT
C. Penicilin G is more allergic than penicillin V
D. None of the above

# Which of the following is the characteristic of tetracycline stains ?
A. There is less deposition in dentin as compared to that in enamel
B. is always accompanied by hypoplastic defects
C. Stains are dark brown in color
D. Staines teeth fluoresce light yellow under UV light

# Drugs which cause ototoxicity and circumoral paraesthesia are :
A. Antileprotic drugs
B. Antitubercular drugs
C. Streptomycin
D. Chloramphenicol

# Ivermectin is indicated in :
A. Scabies
B. Intestinal nematode infection
C. Filariasis
D. All of the Above

# Cross resistance of isoniazide is seen with :
A. Rifampicin
B. Ethionamide
C. Cycloserine
D. Ethambutol

# Metronidazole :
A. has no side efffects
B. is used in management of ANUG (Acute necrotising ulcerative gingivitis)
C. is mainly concentrated in saliva
D. is active against gram positive aerobes

# All of the following drugs are contraindicated in patients with G6PD deficiency except :
A. Cotrimoxazole
B. Furazolidone
C. Nalidixic acid
D. Ceftriaxone

# Which of the following is a fourth generation cephalosporin ?
A. Ceftriaxone
B. Cefaclor
C. Cefuroxime
D. Cefepime

# All of the following are the features of streptomycin except :
A. It is an antitubercular drug
B. It can be given orally
C. Effective against gram negative organisms
D. None of the above

# Cyclosporin is used as an :
A. Anticancer drug
B. Antibiotic
C. Antiarrhythmic
D. Immunosupressant

# Tetracycline when given to pregnant women can cause :
A. Acute hepatic necrosis
B. Discoloration / staining of hard structures of foetus
C. Increased intracranial pressure in infant
D. All

# Best treatment of Candidiasis is :
A. Mycostatin
B. Amphotericin
C. Antibiotics
D. None of the above

# All of the following drugs are primarily bacteriostatic except :
A. Sulphonamide
B. Chloramphenicol
C. Ethambutol
D. Rifampin

# Which of the following is first generation oral cephalosporin ?
A. Cephapirin
B. Cefadroxil
C. Cefaclor
D. Cefixime

# Which of the following penicillins has the best gram negative spectrum ?
A. Methicillin
B. Ampicillin
C. Penicillin V
D. Cefixime

# True about aminoglycoside is all except :
A. are bacteriostatic
B. distributed only extracellularly
C. excreted unchanged in urine
D. Teratogenic

# Which of the following antibiotics is found at much higher concentrations in cervicular fluid than in serum ?
A. Clindamycin
B. Penicillin
C. Tetracycline
D. Metronidazole

# True about amoxyxillin in comparison to ampicillin is :
A. Higher oral bioavailability
B. Lower oral bioavailability
C. Equal oral bioavailability
D. Can be given parenterally

# Drug of choice to treat severe fungal infection in AIDS is :
A. Acyclovir
B. Ketoconazole
C. Aerosolized pentamidine
D. Didanosine

# An aminoglycoside that is often combined with polymyxin and bacitracin for the treatment of topical infection is :
A. Gentamycin
B. Tetracycline
C. Azetronam
D. Neomycin

# Erythromycin is :
A. Cidal in action
B. Cidal in high concentration
C. Static in action
D. All of these

# Povidine iodine is used for :
A. Burns
B. Tinea
C. Non specific vaginitis
D. All of the above

# Identify the drugs useful against Pseudomonas infection :
A. Ticarcillin
B. Ceftazidime
C. Amoxycillin
D. All of the above

# B lactam antibiotics are:
A. Penicillin
B. Imipenem
C. Cephalosporins
D. All of the above

# Aminoglycosides :
A. accumulate in renal failure
B. inhibit protein synthesis
C. effective against gram negative infections
D. all of the above

# Disseminated candidiasis requires intensive therapy with :
A. Nystatin
B. Amphotericin
C. Interferons
D. Thiobendazole

# Macrolides are the choice of drugs in :
A. Atypical pneumonia by mycoplasma
B. Tetanus
C. Gonorrhoea
D. Chlamydia trachomatis

# The administration of penicillin G along with probenecid results in :
A. Increased excretion of probenecid in feces and perspiration
B. increased excretion of probenecid in urine
C. Increased metabolism of penicillin G
D. Decreased renal excretion of penicillin G

# Sulfonamides mainly interferes with the bacterial :
A. transcription mechanisms
B. Translation
C. Ribosomal functions

# All of the following drugs are components of the MOPP cancer chemotherapy regimen except :
A. Procarbazine
B. Vincristine
C. Meclorethamine
D. Methotrexate

# Which of the following antibacterials should not be used with d- tubocurarine ?
A. Norfloxacin
B. Streptomycin
C. Doxycycline
D. Cefotaxime

# Which of the following drugs is an antipseudomonal penicillin ?
A. Cephalexin
B. Cloxacillin
C. Piperacillin
D. Dicloxacillin

# Clavulanic acid is given in combination with amoxicillin in order to :
A. reduce the risk of allergic reactions
B. prolong amoxicillin's half life
C. reduce the severity of diarrhea
D. extend amoxicillin's antibacterial spectrum

# Cephalosporin active against Pseudomonas aeruginosa is :
A. Cefoperazone
B. Cefaclor
C. Ceftriaxone
D. Cefotaxime

# All of the following are therapeutic uses of penicillin G except :
A. Bacterial meningitis
B. Rickettsial infection
C. Syphilis
D. Anthrax

# All of the following are topically used sulphonamides except:
A. Sulphacetamide
B. Sulphadiazine
C. Silver sulphadiazine
D. Mafenide

# The group of antibiotics which possess additional anti-inflammatory and immunomodulatory activities is :
A. Tetracyclines
B. Polypeptide antibiotics
C. Fluoroquinolones
D. Macrolides

# One of the following is not penicillinase susceptible :
A. Amoxicillin
B. Penicillin G
C. Piperacillin
D. Cloxacillin

# INH induced neuropathy is treated with :
A. Thiamine
B. Pyridoxine
C. Niacin
D. Riboflavin

# All of the following antibacterial agents act by inhibiting cell wall synthesis except:
A. Carbapenems
B. Monobactams
C. Cephamycins
D. Nitrofurantoin

# Which of the following is not a broad spectrum antibiotic ?
A. Tetracycline
B. Chloramphenicol
C. Doxycycline
D. Cephalosporins

# Nevirapine is a :
A. Protease inhibitor
B. Nucleoside reverse transcriptase inhibitor
C. Non nucleoside reverse transcriptase inhibitor
D. Fusion inhibitor

# Which of the following antibiotics is not used in the treatment of infectious mononucleosis ?
A. Ampicillin
B. Gentamycin
C. Erythromycin
D. Ciprofloxacin

# A diabetic patient developed cellulitis due to Staphylococcus aureus , which was found to be methicilin resistant. All of the following antibiotics will be appropriate except:
A. Vancomycin
B. Imipenem
C. Teichoplanin
D. Linezolid

# Which of the following is associated with neutropenia ?
A. Doxorubicin
B. Vinblastin
C. Cisplatin
D. Methotrexate

# Which of the following drug does not show renal toxicity ?
A. Gentamycin
B. Streptomycin
C. Methoxyprenaline
D. Isoflurane

# Which of the following is a third generation cephalosporin ?
A. Cefeperazone
B. Cefuroxime
C. Cefoxitin
D. Cefadroxil

# Topical antifungal agent in Candidiasis is :
A. Clotrimazole
B. Cotrimoxazole
C. Ornidazole
D. Propranolol

# Which drug can be safely used in lactating mothers?
A. Ampicillin
B. Chloramphenicol
C. Ciprofloxacin
D. Erythromycin

# AIDS is a disease of the immune system primarily affecting:
A. Granulocytes
B. Immunoglobulins
C. Opsonins
D. T lymphocytes

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