Dentosphere : World of Dentistry

Major risk factor for venous thrombosis:

Which of the following is a major risk factor for venous thrombosis?

a. Smoking

b. High cholesterol

c. Hypertension

d. Diabetes mellitus

e. Cancer

The correct answer is E. Cancer.

Venous thrombosis, including deep vein thrombosis and pulmonary embolism, occurs at an annual incidence of about 1 per 1000 adults. Rates increase sharply after around age 45 years, and are slightly higher in men than women in older age. Major risk factors for thrombosis, other than age, include exogenous factors such as surgery, hospitalization, immobility, trauma, pregnancy and the puerperium and hormone use, and endogenous factors such as cancer, obesity, and inherited and acquired disorders of hypercoagulation.

Ref: Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007;44(2):62-69. doi:10.1053/j.seminhematol.2007.02.004

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Commonest inherited cause of thrombosis

# Commonest inherited cause of thrombosis in Caucasians is:

a. Protein S deficiency

b. Factor V leiden mutation

c. Anti thrombin III deficiency

d. Protein C deficiency

The correct answer is B. Factor V Leiden mutation.

Factor V Leiden (G1691A or arg 506 glu substitution) and prothrombin (G 20210 A) are rare in African and orientals but they have prevalence in whites, highest prevalence of heterozygotes (11–14%) is reported in Sweden and Arabs.

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