Commonest inherited cause of thrombosis

# Commonest inherited cause of thrombosis in Caucasians is:
a. Protein S deficiency
b. Factor V leiden mutation
c. Anti thrombin III deficiency
d. Protein C deficiency

The correct answer is B. Factor V Leiden mutation.

Factor V Leiden (G1691A or arg 506 glu substitution) and prothrombin (G 20210 A) are rare in African and orientals but they have prevalence in whites, highest prevalence of heterozygotes (11–14%) is reported in Sweden and Arabs.

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