Commonest inherited cause of thrombosis

# Commonest inherited cause of thrombosis in Caucasians is:

a. Protein S deficiency

b. Factor V leiden mutation

c. Anti thrombin III deficiency

d. Protein C deficiency

The correct answer is B. Factor V Leiden mutation.

Factor V Leiden (G1691A or arg 506 glu substitution) and prothrombin (G 20210 A) are rare in African and orientals but they have prevalence in whites, highest prevalence of heterozygotes (11–14%) is reported in Sweden and Arabs.

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# Which of the following is the strongest activator of platelet?

 # Which of the following is the strongest activator of platelet? 

a. Thrombin 

b. Serotonin 

c. Thromboxane A2 

d. Epinephrine

The correct answer is: A. Thrombin.

Strong activator: Thrombin Collagen ADP, Shear

Weak: Epinephrine Thromboxane A2/Prostoglandin H2 Serotonin Platelet activating factor Vasopressin Thrombospondin-1 Thrombolytic agent

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Most common cause of thrombocytopenia in children is:

# Most common cause of thrombocytopenia in children is:

a. Aplastic anemia 

b. ITP

c. TTP 

d. Drug induced

The correct answer is B. ITP.

ITP is the most common cause of acquired severe thrombocytopenia and 50% of ITP cases are children, i.e. < 10 years of age. 

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One unit of random donor platelet ideally increases the platelet count in an adult by:

 # One unit of random donor platelet ideally increases the platelet count in an adult by: 

a. 5000 

b. 10000 

c. 15000 

d. 20000

The correct answer is: a. 5000.

The increment in platelet count depends on many factors but if all other factors are absent then 1 unit of whole blood derived random platelet increases the platelet count by 5,000/mm3 per square metre. So in a person of BSA 2 m2. It should raise by 10000/mm3 and of 1.5 m2 by 7500/mm3 respectively. 

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