General Pathology MCQs - Cell in Health and Disease

# Coagulative necrosis is:
A. Characteristic of focal bacterial infections
B. Characteristic of hypoxic death
C. Characterized by loss of tissue architecture
D. None of the above

# Dystrophic calcification are calcifications seen in:
A. Skin layers
B. Salivary glands
C. Normal tissues
D. Dead Tissue


# Diabetic gangrene is caused by:
A. Vasospasm
B. Peripheral neuritis
C. Atherosclerosis
D. None of the above

# Liquefactive necrosis is commonly seen in:
A. Brain
B. Lung
C. Liver
D. Spleen

# Stain used for demonstration of amyloid is:
A. Congo Red
B. Masson's Trichrome
C. Vonkosa
D. Reticulin

# 'Physiologic programmed cell death' is termed as:
A. Apoptosis
B. Lysis
C. Autolysis
D. Autopsy

# Amyloidosis is commonly associated with:
A. Chronic osteomyelitis
B. Periostitis
C. Acute osteomyelitis
D. Multiple myeloma

# Metastatic calcifications are seen in:
A. Hypoparathyroidism
B. Vitamin D deficiency
C. Hypercalcemia
D. All of the above

# Which of the following is correctly matched?
A. Coagulative necrosis - Tuberculosis
B. Caseation - Yellow fever
C. Fat necrosis - Pancreatitis
D. Gumma - Infarction


# Cellular swelling and fatty change are example of:
A. Reversible injury
B. Irreversible injury
C. Both A and B
D. None of the above

# Hypoxic death leads to:
A. Liquefactive necrosis
B. Coagulative necrosis
C. Caseous necrosis
D. Fat necrosis

# Pyknosis is characterized by:
A. Nuclear basophilia
B. Nuclear shrinkage
C. Nucleus disintegration
D. Nucleolus disintegration

# Which of the following is correct?
A. Pyknosis - Shrinkage of Nucleus
B. Karyolysis - Dissolution of Nucleus
C. Karyorrhexis - Fragmentation of Nucleus
D. All of the above

# Gangrene is the death of a part accompanied by:
A. Suppuration
B. Putrefaction
C. Calcification
D. Coagulation

# The hormone dependent shedding of endometrium is an example of :
A. Necrosis
B. Autolysis
C. Apoptosis
D. None of the above

# Mallory's degeneration seen in alcoholic liver disease is a form of:
A. Hyaline degeneration
B. Amyloid degeneration
C. Hydropic degeneration
D. Fatty degeneration

# Primary amyloidosis occurs in:
A. Multiple myeloma
B. Tuberculosis
C. Hodgkin's disease
D. Chronic osteomyelitis

# True statement about primary amyloidosis is:
A. It is more common in heart, skin, and skeletal tissue
B. 70% of cases don't have any associated disease
C. 50% of cases have some form of plasma cell dyscrasias such as multiple myeloma
D. All of the above

# Amyloidosis most commonly occurs in:
A. Kidney
B. Spleen
C. Liver
D. Heart

# Synthesis of DNA occurs in which phase?
A. G1
B. G2
C. S
D. M

# Apoptosis is:
A. single cell necrosis
B. intracytoplasmic accumulation
C. degenerative change
D. neoplastic change in the cell

# Caseation necrosis is suggestive of:
A. Tuberculosis
B. Sarcoidosis
C. Leprosy
D. Midline lethal granuloma

# Severe generalized edema is called as:
A. Myxoedema
B. Pitting edema
C. Anasarca
D. Dependent edema

# Apoptosis is suggestive of:
A. Liquefaction necrosis
B. Coagulative necrosis
C. Neo- angiogenesis
D. Epithelial dysplasia

# Hydrolytic degeneration is characterized by:
A. Caseation
B. Coagulation
C. Liquefaction
D. Fibrinoid

# Secondary amyloidosis is seen most commonly in:
A. Actinomycosis
B. Tuberculosis
C. Rabies
D. Secondary Lues

# Tigered effect of heart is seen in:
A. Fatty change
B. Hyaline change
C. Amyloidosis
D. Atrophy

# The combination of rest pain, color changes, oedema, and hyperaesthesia are seen in:
A. Gangrene
B. Pregangrene
C. Necrosis
D. Vasculitis


# The activation of caspases is likely to lead to:
A. apoptotic cell death
B. blood coagulation
C. mitotic cell division
D. G1 to S phase of cell cycle

# The dominant histologic feature of infarction is:
A. Liquefactive necrosis
B. Coagulative necrosis
C. Chronic inflammation
D. Scar tissue

# Which of the following is not true of dystrophic calcification?
A. Occurs in damaged tissue
B. Tuberculous lesion
C. Atherosclerotic lesions
D. Serum calcium levels are high

# The protein found in the amyloid deposits in senile systemic amyloidosis is:
A. AL protein
B. A2 microglobulin
C. A amyloid protein
D. Transthyretin

# Which of the following is associated with defective apoptosis and increased cell survival?
A. Neurodegenerative diseases
B. Autoimmune disorders
C. Myocardial infarction
D. Stroke