Xeroderma pigmentosum is characterized by:

# Xeroderma pigmentosum is characterized by:
A. Autosomal dominant inheritance
B. Inability to repair sunlight induced damage to DNA
C. Irregular accumulation of melanin in the basal cell layer
D. Acanthosis of epithelium with elongation of rete pegs


The correct answer is B. Inability to repair sunlight induced damage to DNA

Xeroderma Pigmentosum
- Inherited disorder involving defective DNA repair genes.
- Increased risk for the development of cancers of the skin when exposed to the UV rays.
- UV light causes crosslinking of pyrimidine residues, thus preventing normal DNA replication.
- Such DNA damage is repaired by the nucleotide excision repair (NER) pathway. Several proteins and genes are involved in NER, and an inherited loss of any one can give rise to xeroderma pigmentosum.


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