Gene therapy targeting the germ-line is:

 # Gene therapy targeting the germ-line is:

A. Heritable

B. Non heritable

C. Sometimes heritable

D. Unrelated to heritability

The correct answer is: A. Heritable

Germ-line gene therapy involves modifying DNA in germ cells (sperm, ova, or their precursors), which integrate into the genome and are transmitted to future generations, making the genetic changes heritable. This contrasts with somatic gene therapy, which targets non-reproductive cells and is non-heritable (option B). Option C is incorrect as heritability is inherent to germ-line targeting, and option D is irrelevant since heritability is the defining feature. Ethical and regulatory concerns limit germ-line therapy in humans, but the biological principle remains clear.