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Cause of osteogenesis imperfecta is:

# Cause of osteogenesis imperfecta is:
A. Defect in type I collagen
B. Defect in type II collagen
C. Defect in maturation process
D. Defect in calcification process


The correct answer is A. Defect in type I collagen.

Osteogenesis imperfecta (OI) is a serious disease, the molecular pathogenesis of which is being elucidated and it bears a superficial relatedness to dentinogenesis imperfecta, a milder condition affecting mesodermal tissues. It is a condition resulting from abnormality in the type I collagen, which most commonly manifests as fragility of bones. Although osteogenesis imperfecta is generally recognized as representing a hereditary autosomal dominant characteristic, autosomal recessive and nonhereditary types also occur.

Reference: Shafer’s Textbook of ORAL PATHOLOGY, 7th Edition, Page No: 699


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