# Enzyme responsible for breakdown of ground substance is:
a) Hyaluronidase
b) Coagulase
c) Phosphorylase
d) Acid phosphatase
The correct answer is A. Hyaluronidase.
Collagenase is responsible for the breakdown of periodontal fibers in periodontitis. It is released by bacteria (P. gingivalis mostly), polymorpho-nuclear leukocytes, and some populations of fibroblasts. Hyaluronidase causes the breakdown of ground substances and helps in the spread of inflammation (cellulitis).
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