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Tetracycline cause tooth discoloration due to formation of:

 # Tetracycline cause tooth discoloration due to formation of:
A. Calcium oxalate
B. Orthophosphate
C. Tetracalcium phosphate
D. Calcium oxide


The correct answer is B. Orthophosphate.

- Presence of tetracycline in the bloodstream promotes deposition of the drug in the developing enamel and dentin of teeth and bones by binding to calcium to form tetracycline-calcium-orthophosphate.

- The minimum amount required for tooth discoloration is 21 mg/kg body weight. 
- The complex causes discoloration upon eruption and exposure to sun (UV light).
 
# The discoloration appears as:
a) Oxytetracycline (Terramycin)  = Light yellow
b) Tetracycline (Achromycin), Demeclocycline = Yellow
c) Synthetic tetracycline (Minocycline) = Green to dark gray
d) Chlortetracycline (Aureomycin) = Gray - brown (Worst staining)
e) Doxycycline and Oxytetracycline = Light Yellow (least staining)

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