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FALSE regarding biotransformation of drugs is:

 # FALSE regarding biotransformation of drugs is:
A. It usually converts a drug into its lipid soluble non ionized form
B. It generally involves modifications of the chemical structure of the drug
C. It principally occurs in the microsomal enzyme system of the liver
D. The rate may vary significantly between species



The correct answer is A.  It usually converts a drug into its lipid soluble non ionized form.

Biotransformation involves the conversion of a lipid soluble non ionized form of a drug into its more water soluble metabolites.

Biotransformation increases the absorption of the drug into the bloodstream, enhancing the bioavailability of the drug. Water soluble drugs are also easily excreted in the urine.

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