Intended target cells of H2 histamine receptor blockers

 # Which of the following is the intended target of H2 histamine receptor blockers?
A. Juxtaglomerular cells
B. Basophils
C. Arterial endothelial cells
D. Parietal cells
E. Mast cells

The correct answer is D. Parietal cells.

Histamine stimulates the H2 receptor of the parietal cells of the stomach and is released by basophils and mast cells. 

H2 receptor stimulation induces a proton release into the stomach lumen, decreasing the pH.

H2 receptor blockers reduce the amount of acid in the stomach.

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