Differential Diagnosis in Dentistry Part 1

1 . Intra-epithelial bulla are seen in:

  • Herpes Simplex
  • Herpes Zoster
  • Chicken Pox
  • Pemphigus
  • Familial Benign Pemphigus (Hailey - Hailey Disease )
  • Epidermolysis bullosa - dystrophic recessive form
  • Oral lesions of Erythema Multiforme

2. Subepithelial Bulla are seen in:

  • Pemphigoid
  • Bullous Pemphigoid
  • Bullous Lichen Planus
  • Dermatitis herpetiformis
  • Epidermolysis bullosa
  • Skin lesions of Erythema Multiforme

3. Tzanck Cells are Seen in:

  • Herpes
  • Pemphigus

4. Multinucleated Giant Cells are seen in:

  • Cherubism
  • Hyperparathyroidism
  • Aneurysmal bone cyst
  • Giant cell granulomas
  • Osteoclastoma
  • Osteosarcoma
  • Herpes
  • Leprosy ( Langerhans Giant Cells )
  • Eosinophilic Granuloma

5. Psoriasis form of lesions with Monro's abscess are seen in :

  • Benign migratory glossitis 
  • Psoriasis 
  • Reiters syndrome (Micro-abscess formation is also seen in Vitamin A deficiency) 

6. Ghost cells are seen in :

  • Odontoma 
  • Craniopharyngioma 
  • Ameloblastic fibroodontoma 
  • Calcifying epithelial odontogenic cyst 

7. Bence Jones protein is diagnostic of :

  • Multiple myeloma (important feature) 
  • Polycythemia vera 
  • Leukemia 
  • Solitary myeloma 

8. Blue sclera is seen in :

  • Osteogenesis imperfecta 
  • Marfan's syndrome 
  • Cherubism 
  • Ehlers-Danlos syndrome 
  • Osteopetrosis 
  • Fetal rickets 

9. Abnormal dentino-enamel junction is seen in :

  • Dentinogenesis imperfecta 
  • Ehlers-Danlos syndrome 

10. Rushton bodies are seen in:

  • Periapical cyst 
  • Dentigerous cyst 
  • Neonatal cyst 

11. Nikolsky's sign is seen in:

  • Pemphigus 
  • Familial benign chronic pemphigus 
  • Epidermolysis bullosa (dystrophic recessive) 

12. Pseudoepitheliomatous hyperplasia is seen in :

  • Granular Cell Myoblastoma 
  • Blastomycosis 
  • Papillary hyperplasia 
  • DLE 
  • Squamous cell carcinoma 

13. Sunray or Sunburst appearance is seen in :

  • Osteogenic sarcoma 
  • Central hemangioma 
  • Ewing's sarcoma 

14. Onion peel appearance is seen in: 

  • Ewing's sarcoma 
  • Garre's osteomyelitis 
  • Caffey's disease 

15. Crew-cut or Hair-on-end appearance is seen in :

  • Thalassemia 
  • Sickle cell anemia 

16. Ground glass appearance is seen in:

  • Primary hyperparathyroidism 
  • Monostotic fibrous dysplasia 
  • Cherubism 

17. Widening of Periodontal Ligament is seen in :

  • Osteosarcoma 
  • Scleroderma 
  • Trauma from occlusion 

18. Hypercementosis is seen in :

  • Paget's disease 
  • Hyperpituitarism (Gigantism) 

19. Obliteration of periodontal ligament space is seen in :

  • Hypercementosis
  • Ankylosis
  • Hypofunction of teeth
  • Paget's Disease

20. 'Cotton Wool' appearance is seen in:

  • Paget's Disease (Osteitis deformans)
  • Chronic sclerosing diffuse osteomyelitis
  • Fibrous dysplasia
  • Cemento-osseous dysplasia

21. Multiple unerupted teeth are seen in:

  • Dentin Dysplasia
  • Cleidocranial Dysplasia
  • Hypothyroidism
  • Cherubism

22. Periosteal new bone formation is seen in :

  • Garre's Osteomyelitis
  • Hypervitaminosis A
  • Caffey's Disease or Infantile Cortical Hyperostosis
  • Syphilis
  • Leukemia
  • Ewing's Sarcoma

23. Cafe -au- lait pigmentation is seen in:

  • Neurofibroma
  • Peutz-Jegher's Syndrome
  • Polyostotic Fibrous Dysplasia
  • Hypothyroidism


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