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Folic acid deficiency

# Folic acid deficiency is associated with administration of:
A. Phenytoin
B. Chloramphenicol
C. Isoniazide
D. Streptomycin


The correct answer is A. Phenytoin.

Folic acid deficiency can be caused by drugs that interfere with folate absorption or metabolism. Phenytoin, some other anticonvulsants, oral contraceptives, and isoniazide can cause Folic acid deficiency by interfering with Folic acid absorption. Other drugs such as methotrexate and, to a lesser extent, trimethoprim and pyrimethamine, inhibit dihydrofolate reductase and may result in a deficiency of folate cofactors and ultimately in megaloblastic anemia.

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